Evidence map›Paper›PMID 33149301›Full record

ArticleNature2020

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.

Lucia M Moreira, Abhijit Takawale, Mohit Hulsurkar, David A Menassa, Agne Antanaviciute, Satadru K Lahiri, Neelam Mehta, Neil Evans, Constantinos Psarros, Paul Robinson and 26 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation.Annual review of pharmacology and toxicology · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Gene Therapy for Inherited Cardiac Arrhythmias.Journal of cardiovascular translational research · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Atrial Fibroblasts-Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 7 institutions in 6 countries.

Lucia M Moreira *Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0001-8168-1538
Abhijit Takawale *Research Centre, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada.
Mohit HulsurkarCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0595-6661
David A MenassaClinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Agne AntanaviciuteMedical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9019-2215
Satadru K LahiriCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9502-1530
Neelam MehtaDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Neil EvansDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-5458-6065
Constantinos PsarrosDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Paul RobinsonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Alexander J SparrowDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-3354-3314
Marc-Antoine GillisDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Neil AshleySingle-Cell Genomics Facility, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Patrice NaudDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Javier Barallobre-BarreiroKing's British Heart Foundation Centre, King's College London, London, UK.
Konstantinos TheofilatosKing's British Heart Foundation Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6799-0553
Angela LeeDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Mary NorrisDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Michele V ClarkeDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.
Patricia K RussellDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.
Barbara CasadeiDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-6801-1617
Shoumo BhattacharyaDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Jeffrey D ZajacDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.
Rachel A DaveyDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.
Martin SiroisDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Adam MeadMedical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-8522-1002
Alison SimmonsMedical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Manuel MayrKing's British Heart Foundation Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0002-0597-829X
Rana SayeedCardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-2887-1874
George KrasopoulosCardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford, UK.
Charles RedwoodDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Keith M ChannonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Jean-Claude TardifDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Xander H T WehrensCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5044-672X
Stanley Nattel *Research Centre, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-5565-3311
Svetlana ReillyDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, UK. svetlana.reilly@cardiov.ox.ac.uk.ORCID http://orcid.org/0000-0003-1231-1239
John Radcliffe Hospital · GBMcGill University · CAThe University of Melbourne · AUUniversity of Oxford · GBBaylor College of Medicine · USKing's College London · GBMontreal Heart Institute · CA

Funding

British Heart Foundation CH/09/003/26631British Heart Foundation CH/12/3/29609British Heart Foundation CH/16/3/32406British Heart Foundation FS/16/5/32054British Heart Foundation PG/13/5/29973British Heart Foundation PG/15/35/31403British Heart Foundation RG/07/003/23133British Heart Foundation RG/10/17/28553British Heart Foundation RG/12/5/29576British Heart Foundation RG/16/12/32451British Heart Foundation RG/16/14/32397British Heart Foundation RG/17/10/32859British Heart Foundation RG/18/1/33351Medical Research Council MC_PC_MR/S025952/1Medical Research Council MC_UP_1502/3Medical Research Council MC_UU_00008/7Medical Research Council MC_UU_12010/7Medical Research Council MR/M00919X/1Medical Research Council MR/S036377/1Wellcome Trust 203141/Z/16/Z
6 · The paper itself

Abstract

Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly to the risk of stroke in humans

Indexed as

Paracrine CommunicationAnimalsArrhythmias, CardiacAtrial FibrillationCalcitoninCollagen Type IFemaleFibrinogenFibroblastsFibrosisHeart AtriaHumansMaleMiceMyocardiumMyocytes, CardiacCalcitoninCollagen Type IFibrinogenReceptors, Calcitonin

Identifiers

PMID33149301
OpenAlexW3097722104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.