ArticleScientific reports2020
Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson's disease over five years follow-up.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The prevalence of gastrointestinal dysfunction and its impact on quality of life in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Constipation in a Large Online Cohort of Persons with Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Discriminating between proposed Brain-First and Body-First Parkinson's disease using conventional and radiomics-enhanced dopamine transporter SPECT image analysis.NPJ Parkinson's disease · 2025Article
- Prevalence and Clinical Characteristics of Mirror Movements in a Chinese Cohort of Parkinson's Disease Patients.Annals of Indian Academy of Neurology · 2025Article
- Investigation of nonmotor symptoms and their clinical correlates in patients with Parkinson's disease.Neurodegenerative disease management · 2025Article
- Assessment tools for cognitive performance in Parkinson's disease and its genetic contributors.Frontiers in neurology · 2024Article
- Bowel movement frequency and difficult defecation using constipation assessment scale in patients with isolated REM sleep behavior disorder.Clinical parkinsonism & related disorders · 2024Article
- Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records.Frontiers in aging neuroscience · 2024Article
- Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation.BMC pediatrics · 2023Article
- The brain-first vs. body-first model of Parkinson's disease with comparison to alternative models.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Association of sleep duration with chronic constipation among adult men and women: Findings from the National Health and Nutrition Examination Survey (2005-2010).Frontiers in neurology · 2022Article
- Diagnostic value of skin RT-QuIC in Parkinson's disease: a two-laboratory study.NPJ Parkinson's disease · 2021Article
- An Update on Medical and Surgical Treatments of Parkinson's Disease.Aging and disease · 2021Review
- Early constipation predicts faster dementia onset in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease.Current neuropharmacology · 2021Review
- The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson's Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline.Journal of Parkinson's disease · 2021Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Constipation and REM sleep behaviour disorder (RBD) are the earliest non-motor manifestations of Parkinson's disease (PD). Among non-motor symptoms of PD, it is unclear whether constipation and RBD at early stages of PD are related to cognitive outcomes at later stages. Herein, this study aims to investigate whether the presence of constipation and RBD have an impact on future cognitive outcomes in PD. Access to Parkinson's Progression Markers Initiative (PPMI) database of 360 PD patients with longitudinal observation was requested. Constipation, probable RBD (pRBD) and neuropsychological task scores of PD patients were assessed at baseline and after 5 years. Linear mixed-effects modelling, controlling for gender, age, years of education and LEDD was used to evaluate the association between baseline constipation, pRBD and cognitive performance on follow-up. Gender differences in neuropsychological test performances were found, with men having worse global cognition, speed-attention processing, verbal learning and memory than women at early stages of the disease. We found constipation and pRBD are strongly associated with future decline in some cognitive measures among PD patients, more prominently in men. Our data suggest that early assessment of pRBD and constipation may allow better understanding of the progression of cognitive changes in later phases of PD.
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