Evidence map›Paper›PMID 33149205›Full record

Trial reportScientific reports2020

Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia.

Farid Kurniawan, Dicky L Tahapary, Karin de Ruiter, Em Yunir, Nienke R Biermasz, Johannes W A Smit, Taniawati Supali, Erliyani Sartono, Maria Yazdanbakhsh, Pradana Soewondo

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Farid KurniawanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta, 10430, Indonesia.
Dicky L TahaparyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta, 10430, Indonesia. dicky.tahapary@ui.ac.id.
Karin de RuiterDepartment of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Em YunirDivision of Endocrinology and Metabolism, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta, 10430, Indonesia.
Nienke R BiermaszDepartment of Endocrinology and Metabolic Disease, Leiden University Medical Center, Leiden, The Netherlands.
Johannes W A SmitDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Taniawati SupaliDepartment of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Erliyani SartonoDepartment of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Maria YazdanbakhshDepartment of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Pradana SoewondoDivision of Endocrinology and Metabolism, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta, 10430, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults. The levels of IGF-1 and IGFBP3 were measured in 1669 subjects aged ≥ 16 years, before and after receiving four rounds of albendazole 400 mg/day or matching placebo for three consecutive days. Helminth infection status was assessed by microscopy (Kato-Katz) and PCR. Serum free IGF-1 level was significantly lower in helminth-infected subjects [mean difference and 95% CI - 0.068 (- 0.103; - 0.033), P < 0.001 after adjustment for age, sex, body mass index, and fasting insulin level]. There was no difference in IGFBP-3 level between helminth infected versus non-infected subjects. In the whole study population, albendazole treatment significantly increased serum free IGF-1 level [estimate and 95% CI 0.031 (0.004; - 0.057), P = 0.024] whereas no effect was found on the IGFBP-3 level. Our study showed that helminth infection in adults is associated with lower free IGF-1 levels but not with IGFBP-3 and albendazole treatment significantly increases free IGF-1 levels in the study population.Clinical Trial Registration: https://www.isrctn.com/ISRCTN75636394 .

Indexed as

AdultAlbendazoleAnthelminticsCase-Control StudiesChildChild, PreschoolCluster AnalysisFemaleHelminthiasisHumansIndonesiaInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMalePlacebosAlbendazoleAnthelminticsIGF1 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IPlacebos

Identifiers

PMID33149205
PMCPMC7643058

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.