Evidence map›Paper›PMID 33149159›Full record

ArticleNature communications2020

Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae.

Monica I Espinosa, Ricardo A Gonzalez-Garcia, Kaspar Valgepea, Manuel R Plan, Colin Scott, Isak S Pretorius, Esteban Marcellin, Ian T Paulsen, Thomas C Williams

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 126 citations in OpenAlex.

  1. Review
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  3. Article
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  8. Adaptive Laboratory Evolution of Pichia pastoris by Serial Batch Cultivation.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Evolutionary engineering ofScience advances · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Monica I EspinosaDepartment of Molecular Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, 2109, North Ryde, NSW, Australia.
Ricardo A Gonzalez-GarciaAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, 4072, Brisbane, QLD, Australia.
Kaspar ValgepeaAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, 4072, Brisbane, QLD, Australia.
Manuel R PlanAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, 4072, Brisbane, QLD, Australia.
Colin ScottCSIRO Synthetic Biology Future Science Platform, Canberra, ACT, 2601, Australia.ORCID 0000-0001-6110-6982
Isak S PretoriusDepartment of Molecular Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, 2109, North Ryde, NSW, Australia.ORCID 0000-0001-9127-3175
Esteban MarcellinAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, 4072, Brisbane, QLD, Australia.
Ian T PaulsenDepartment of Molecular Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, 2109, North Ryde, NSW, Australia. ian.paulsen@mq.edu.au.
Thomas C WilliamsDepartment of Molecular Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, 2109, North Ryde, NSW, Australia. tom.williams@mq.edu.au.ORCID 0000-0002-0594-3441
The University of Queensland · AUCommonwealth Scientific and Industrial Research Organisation · AUARC Centre of Excellence in Synthetic Biology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Utilising one-carbon substrates such as carbon dioxide, methane, and methanol is vital to address the current climate crisis. Methylotrophic metabolism enables growth and energy generation from methanol, providing an alternative to sugar fermentation. Saccharomyces cerevisiae is an important industrial microorganism for which growth on one-carbon substrates would be relevant. However, its ability to metabolize methanol has been poorly characterised. Here, using adaptive laboratory evolution and

Indexed as

Adaptor Proteins, Signal TransducingAlcohol DehydrogenaseCarbon IsotopesDirected Molecular EvolutionFermentationGTP-Binding ProteinsIndustrial MicrobiologyMass SpectrometryMetabolic EngineeringMetabolomicsMethanolProteomeSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSystems BiologyTranscription FactorsAdaptor Proteins, Signal TransducingADH2 protein, S cerevisiaeAlcohol DehydrogenaseASC1 protein, S cerevisiaeCarbon IsotopesGTP-Binding ProteinsMethanolProteomeSaccharomyces cerevisiae ProteinsTranscription Factors

Identifiers

PMID33149159
PMCPMC7643182
OpenAlexW3094651377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.