ArticleNature communications2020
Polyandry blocks gene drive in a wild house mouse population.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Y-linked editors for invasive rodent control.Molecular biology and evolution · 2026Article
- Integrating mosquito genomics into simulation modeling: opportunities for better-informed biocontrol.Current opinion in insect science · 2026Review
- The Spatial Spread and the Persistence of Gene Drives Are Affected by Demographic Feedbacks, Density Dependence and Allee Effects.Molecular ecology · 2025Article
- Maximising Eradication Potential of Rat Gene Drives Using a Two-Target Homing Rescue Strategy: Spatial Modelling of Empirical Data.Molecular ecology · 2025Article
- Modeling the evolution of Schizosaccharomyces pombe populations with multiple killer meiotic drivers.G3 (Bethesda, Md.) · 2024Article
- A framework for identifying fertility gene targets for mammalian pest control.Molecular ecology resources · 2024Article
- The suppressive potential of a gene drive in populations of invasive social wasps is currently limited.Scientific reports · 2023Article
- Gene drive-mediated population elimination for biodiversity conservation. When you come to a fork in the road, take it.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Leveraging a natural murine meiotic drive to suppress invasive populations.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A meiotic driver alters sperm form and function in house mice: a possible example of spite.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Article
- Meiotic drive in house mice: mechanisms, consequences, and insights for human biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
- Selfish migrants: How a meiotic driver is selected to increase dispersal.Journal of evolutionary biology · 2022Article
- Gene drives for vertebrate pest control: Realistic spatial modelling of eradication probabilities and times for island mouse populations.Molecular ecology · 2022Article
- Novel patterns of expression and recruitment of new genes on theProceedings. Biological sciences · 2022Article
- Gene Editing and Genetic Control of Hemipteran Pests: Progress, Challenges and Perspectives.Frontiers in bioengineering and biotechnology · 2022Review
- The baculum affects paternity success of first but not second males in house mouse sperm competition.BMC ecology and evolution · 2021Article
- Experiments confirm a dispersive phenotype associated with a natural gene drive system.Royal Society open science · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene drives are genetic elements that manipulate Mendelian inheritance ratios in their favour. Understanding the forces that explain drive frequency in natural populations is a long-standing focus of evolutionary research. Recently, the possibility to create artificial drive constructs to modify pest populations has exacerbated our need to understand how drive spreads in natural populations. Here, we study the impact of polyandry on a well-known gene drive, called t haplotype, in an intensively monitored population of wild house mice. First, we show that house mice are highly polyandrous: 47% of 682 litters were sired by more than one male. Second, we find that drive-carrying males are particularly compromised in sperm competition, resulting in reduced reproductive success. As a result, drive frequency decreased during the 4.5 year observation period. Overall, we provide the first direct evidence that the spread of a gene drive is hampered by reproductive behaviour in a natural population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.