Evidence map›Paper›PMID 33148943›Full record

ArticleJournal of microbiology and biotechnology2021

Purification and Characterization of a Thrombolytic Enzyme Produced by a New Strain of

Jorge Frias, Duarte Toubarro, Alexandra Fraga, Claudia Botelho, José Teixeira, Jorge Pedrosa, Nelson Simões

Abstract read
In one paragraph

Article in Journal of microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The living medicine inside us:Gut microbes reports · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jorge FriasCBA - Biotechnology Centre of Azores, Faculty of Sciences and Technology, University of Azores, 9500-321 Ponta Delgada, Açores. Portugal.
Duarte ToubarroCBA - Biotechnology Centre of Azores, Faculty of Sciences and Technology, University of Azores, 9500-321 Ponta Delgada, Açores. Portugal.
Alexandra FragaICVS - Life and Health Research Institute, University of Minho, 4710-057 Braga, Portugal.
Claudia BotelhoCEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.
José TeixeiraCEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.
Jorge PedrosaICVS - Life and Health Research Institute, University of Minho, 4710-057 Braga, Portugal.
Nelson SimõesCBA - Biotechnology Centre of Azores, Faculty of Sciences and Technology, University of Azores, 9500-321 Ponta Delgada, Açores. Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibrinolytic enzymes with a direct mechanism of action and safer properties are currently requested for thrombolytic therapy. This paper reports on a new enzyme capable of degrading blood clots directly without impairing blood coagulation. This enzyme is also non-cytotoxic and constitutes an alternative to other thrombolytic enzymes known to cause undesired side effects. Twenty-four

Indexed as

AnimalsBacillus subtilisBacterial ProteinsBlood CellsBlood CoagulationFemaleFibrinolytic AgentsHemolysisHumansHydrogen-Ion ConcentrationKineticsMolecular WeightProthrombin TimeRatsSheepSubtilisinsBacterial ProteinsFibrinolytic AgentsSubtilisinsBacillus subtilisdirect-acting thrombolytic enzymefibrinolyticsubtilisinthrombolytic

Identifiers

PMID33148943
PMCPMC9705946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.