ArticleJCI insight2020
Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis.
Article in JCI insight, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Choroid plexus volume in multiple sclerosis: a systematic review and meta-analysis of an emerging imaging biomarker.European journal of medical research · 2025Pooled it
- Simultaneous TMagnetic resonance in medicine · 2026Article
- Early-Age Cuprizone Exposure Induces Region-Specific Demyelination and Neuroinflammation in Mice.Neuromolecular medicine · 2026Article
- Microstructure-informed deep learning improves thalamic atrophy segmentation and clinical associations in multiple sclerosis and related neuroimmunological diseases.NeuroImage. Clinical · 2026Article
- Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI.NeuroImage · 2025Article
- A volumetric study of the choroid plexus in neuropsychiatric systemic lupus erythematosus.Scientific reports · 2025Article
- Distinguishing Transient From Persistent Brain Structural Changes in Pediatric Patients With Acute Disseminated Encephalomyelitis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Impairment of spinal CSF flow precedes immune cell infiltration in an active EAE model.Journal of neuroinflammation · 2024Article
- Choroid plexus and perivascular space enlargement in neuropsychiatric systemic lupus erythematosus.Molecular psychiatry · 2024Article
- Longitudinal evaluation of structural brain alterations in two established mouse models of Gulf War Illness.Frontiers in neuroscience · 2024Article
- Antigen B modulates anti-inflammatory cytokines in the EAE model of multiple sclerosis.Brain and behavior · 2023Article
- A review on multiple sclerosis prognostic findings from imaging, inflammation, and mental health studies.Frontiers in human neuroscience · 2023Review
- Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy.Annals of clinical and translational neurology · 2022Article
- Longitudinal changes of deep gray matter shape in multiple sclerosis.NeuroImage. Clinical · 2022Article
- Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Contribution of preclinical MRI to responsible animal research: living up to the 3R principle.Magma (New York, N.Y.) · 2021Article
- Prediction of high and low disease activity in early MS patients using multiple kernel learning identifies importance of lateral ventricle intensity.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain ventricles are part of the fluid compartments bridging the CNS with the periphery. Using MRI, we previously observed a pronounced increase in ventricle volume (VV) in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Here, we examined VV changes in EAE and MS patients in longitudinal studies with frequent serial MRI scans. EAE mice underwent serial MRI for up to 2 months, with gadolinium contrast as a proxy of inflammation, confirmed by histopathology. We performed a time-series analysis of clinical and MRI data from a prior clinical trial in which RRMS patients underwent monthly MRI scans over 1 year. VV increased dramatically during preonset EAE, resolving upon clinical remission. VV changes coincided with blood-brain barrier disruption and inflammation. VV was normal at the termination of the experiment, when mice were still symptomatic. The majority of relapsing-remitting MS (RRMS) patients showed dynamic VV fluctuations. Patients with contracting VV had lower disease severity and a shorter duration. These changes demonstrate that VV does not necessarily expand irreversibly in MS but, over short time scales, can expand and contract. Frequent monitoring of VV in patients will be essential to disentangle the disease-related processes driving short-term VV oscillations from persistent expansion resulting from atrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.