Evidence map›Paper›PMID 33148825›Full record

ArticlemSphere2020

Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1.

Syriam Sooksawasdi Na Ayudhya, Adam Meijer, Lisa Bauer, Bas Oude Munnink, Carmen Embregts, Lonneke Leijten, Jurre Y Siegers, Brigitta M Laksono, Frank van Kuppeveld, Thijs Kuiken and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Positive-strand RNA viruses-a Keystone Symposia report.Annals of the New York Academy of Sciences · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. MYCN in Neuroblastoma: "Old Wine into New Wineskins".Diseases (Basel, Switzerland) · 2021
    Review
  14. Article
  15. Microorganisms · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Syriam Sooksawasdi Na AyudhyaDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Adam MeijerNational Institute for Public Health and the Environment, Centre for Infectious Diseases Research, Diagnostics and Laboratory Surveillance, Bilthoven, The Netherlands.
Lisa BauerDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Bas Oude MunninkDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Carmen EmbregtsDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Lonneke LeijtenDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Jurre Y SiegersDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Brigitta M LaksonoDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Frank van KuppeveldVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Thijs KuikenDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Corine Geurts-van KesselDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Debby van RielDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands d.vanriel@erasmusmc.nl.ORCID 0000-0001-9753-3564
Erasmus MC · NLNational Institute for Public Health and the Environment · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since its emergence in the United States in 2014, enterovirus D68 (EV-D68) has been and is associated with severe respiratory diseases and acute flaccid myelitis. Even though EV-D68 has been shown to replicate in different neuronal cells

Indexed as

Amino Acid SubstitutionVirus ReplicationCapsid ProteinsCell Culture TechniquesCell Line, TumorEnterovirus D, HumanEnterovirus InfectionsHumansKineticsNeural Stem CellsNeuroblastomaVirus InternalizationCapsid Proteinscell culture adaptationenterovirus D68heparan sulfatein vitroneuroblastoma cellsneurotropismpathogenesisreplicationVP1

Identifiers

PMID33148825
PMCPMC7643833
OpenAlexW3097871991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.