SynthesisJournal of neurology, neurosurgery, and psychiatry2021
Prevalence, predictors and prognosis of incidental intracranial aneurysms in patients with suspected TIA and minor stroke: a population-based study and systematic review.
Synthesis in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 34 citations in OpenAlex.
- Estimating Rupture Risk of Intracranial Aneurysms: What We Know, What We Do Not Know, and What We Need.Stroke · 2026Review
- Unruptured middle cerebral artery bifurcation aneurysms: long-term outcomes of endovascular techniques from an 'endovascular-first' policy center.Neuroradiology · 2025Article
- Management and Outcomes of Multiple Unruptured Cerebral Aneurysms: A Descriptive Cohort Analysis.Brain sciences · 2025Article
- Predicting Cerebral Aneurysm Rupture: The Role of Computational Fluid Dynamics.Neuroimaging clinics of North America · 2025Review
- Inter-modality correlation across invasive and noninvasive angiography in the three-dimensional assessment of cerebral aneurysms.Surgical neurology international · 2025Article
- Nomogram-based geometric and hemodynamic parameters for predicting the growth of small untreated intracranial aneurysms.Neurosurgical review · 2024Article
- False positive angiographic aneurysm of the anterior segment of the M1 bifurcation of the middle cerebral artery: a case report.Frontiers in neurology · 2023Article
- Prevalence and prognosis of acute ischemic stroke coexisting with unruptured intracranial aneurysms.Frontiers in neurology · 2023Article
- Prevalence and risk factors of unruptured intracranial aneurysms in ischemic stroke patients - A global meta-analysis.Surgical neurology international · 2023Article
- Endovascular management of intracranial aneurysms at Chris Hani Baragwanath Academic Hospital.SA journal of radiology · 2023Article
- Article
- Risk Factors for Cerebral Aneurysm Rupture in Mongolia.Clinical neuroradiology · 2022Article
- Article
- Integrated analysis identifies the IL6/JAK/STAT signaling pathway and the estrogen response pathway associated with the pathogenesis of intracranial aneurysms.Frontiers in immunology · 2022Article
- Genome-wide polygenic risk impact on intracranial aneurysms and acute ischemic stroke.PloS one · 2022Article
- Prevalence and Risk Factors for Unruptured Intracranial Aneurysms in the Population at High Risk for Aneurysm in the Rural Areas of Tianjin.Frontiers in neurology · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionUnruptured intracranial aneurysms (UIAs) are common incidental imaging findings, but there are few data in patients with transient ischaemic attack (TIA)/stroke. The frequency of UIA might be higher due to shared risk factors, but rupture risk might be reduced by intensive secondary prevention. We determined the prevalence and prognosis of UIA in patients with suspected TIA/minor stroke.
methodsAll patients referred to the population-based Oxford Vascular Study (2011-2020) with suspected TIA/minor stroke and non-invasive angiography were included. We determined the prevalence of incidental asymptomatic UIA and the risk of subsequent subarachnoid haemorrhage (SAH) by follow-up on intensive medical treatment, with guideline-based monitoring/management. We also did a systematic review of UIA prevalence/prognosis in cohorts with TIA/stroke.
findingsAmong 2013 eligible patients, 95 (4.7%) had 103 previously unknown asymptomatic UIA. Female sex (OR 2.3, 95% CI 1.5 to 3.7), smoking (2.1, 1.2 to 3.6) and hypertension (1.6, 1.0 to 2.5) were independently predictive of UIA, with a prevalence of 11.1% in those with all three risk factors. During mean follow-up of 4.5 years, only one SAH occurred: 2.3 (95% CI 0.3 to 16.6) per 1000 person-years. We identified 19 studies of UIA in TIA/stroke cohorts (n=12 781), all with either symptomatic carotid stenosis or major acute stroke. The pooled mean UIA prevalence in patients with TIA/stroke was 5.1% (95% CI 4.8 to 5.5) and the incidence of SAH was 4.6 (95% CI 1.9 to 11.0) per 1000 person-years.
interpretationThe 5% prevalence of UIA in patients with confirmed TIA/minor stroke is likely higher than that in the general population. However, the risk of SAH on intensive medical treatment and guideline-based management/monitoring is low.
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