Evidence map›Paper›PMID 33148748›Full record

ArticleBMJ open2020

TOP-ID: a Delphi technique-guided development of a prescription and deprescription tool for adults with intellectual disabilities.

Sophie Lonchampt, Fabienne Gerber, Jean-Michel Aubry, Jules Desmeules, Marie Besson, Markus Kosel

Abstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophie LonchamptPsychopharmacology Unit, Division of Clinical Pharmacology and Toxicology, Department of Anesthesiology, Pharmacology and Intensive care, Geneva University Hospitals, University of Geneva, Geneva, Switzerland sophie.lonchampt@hcuge.ch.ORCID 0000-0001-5526-0270
Fabienne GerberUnit for Intellectual Disabilities and Autism in Adults, Division of Psychiatric Specialties, Department of Psychiatry, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Jean-Michel AubryDivision of Psychiatric Specialties, Department of Psychiatry and Mental Health, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Jules DesmeulesSchool of Pharmaceutical Sciences of Geneva and Lausanne, Faculty of Science, University of Geneva, Geneva, Switzerland.
Marie BessonPsychopharmacology Unit, Division of Clinical Pharmacology and Toxicology, Department of Anesthesiology, Pharmacology and Intensive care, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Markus KoselUnit for Intellectual Disabilities and Autism in Adults, Division of Psychiatric Specialties, Department of Psychiatry, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAdults with an intellectual disability (AWID) are often polymedicated because of somatic and psychiatric health problems. Besides, they may display challenging behaviours, leading to off-label prescription of psychotropic drugs, without efficacy and with numerous adverse effects. In this context, a prescription/deprescription tool (Tool for Optimising Prescription in Intellectual Disability/TOP-ID) was developed to improve the care of AWID. This paper describes how TOP-ID was designed.

designFour-step consensus-based process involving a review of the literature, eight semistructured interviews and a two-round Delphi process.

settingSeventeen general practices and university and general hospitals from Belgium, France and Switzerland.

participantsEighteen French-speaking physicians from different domains of expertise participated in the Delphi process. PRIMARY AND SECONDARY OUTCOME MEASURES: For the Delphi iteration process, consensus was defined as at least a 65% agreement between the experts.

resultsTwo rounds were needed for the Delphi process. Eighty-one items of the tool were submitted to 18 out of 35 recruited French-speaking experts during the first round. Sixty-nine per cent of the items reached a rate of agreement of 65% or more in that round. Thirteen questions were reformulated and resubmitted for the second Delphi iteration round. All of the statements reached a rate of agreement of 65% or more in the second round.

conclusionTOP-ID is the first prescription-deprescription tool developed specifically for AWIDs in French. It is intended to help prescribers document patient care in order to reduce prescription errors and to improve safety. The next steps of the project include the development of an electronic version of TOP-ID and a utility study.

Indexed as

DeprescriptionsIntellectual DisabilityAdultAgedBelgiumDelphi TechniqueFranceHumansPrescriptionsSwitzerlandadult psychiatryclinical pharmacologyprotocols & guidelines

Identifiers

PMID33148748
PMCPMC7643515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.