Evidence map›Paper›PMID 33148687›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2021

Lekha Pandit, Laura M Cox, Chaithra Malli, Anitha D'Cunha, Timothy Rooney, Hrishikesh Lokhande, Valerie Willocq, Shrishti Saxena, Tanuja Chitnis

Open access · goldAbstract read
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Gut microbial profiles of patients with optic neuritis or myasthenia gravis.The Journal of international medical research · 2025
    Article
  7. Article
  8. The Role of Gut Microbiota in Neuromyelitis Optica Spectrum Disorder.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Frontiers in microbiology · 2024
    Article
  11. Article
  12. Article
  13. Ethanol-ProducingMicroorganisms · 2023
    Article
  14. Review
  15. Review
  16. Article
  17. Increased fecal ethanol and enriched ethanol-producing gut bacteriaFrontiers in cellular and infection microbiology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Lekha PanditFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts. panditmng@gmail.com.ORCID 0000-0002-2269-5312
Laura M CoxFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9564-9894
Chaithra MalliFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Anitha D'CunhaFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Timothy RooneyFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Hrishikesh LokhandeFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Valerie WillocqFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-1892-6456
Shrishti SaxenaFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Tanuja ChitnisFrom the Nitte University (L.P., C.M., A.D.), Mangalore, India; and Ann Romney Center for Neurological Diseases (L.M.C., T.R., H.L., V.W., S.S., T.C.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9897-4422
Brigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo understand the role of gut microbiome in influencing the pathogenesis of neuromyelitis optica spectrum disorders (NMOSDs) among patients of south Indian origin.

methodsIn this case-control study, stool and blood samples were collected from 39 patients with NMOSD, including 17 with aquaporin 4 IgG antibodies (AQP4+) and 36 matched controls. 16S ribosomal RNA (rRNA) sequencing was used to investigate the gut microbiome. Peripheral CD4

resultsMicrobiota community structure (beta diversity) differed between patients with AQP4+ NMOSD and healthy controls (

conclusionOur study described elevated levels of

Indexed as

EubacterialesGastrointestinal MicrobiomeAdultAquaporin 4BacillotaCase-Control StudiesFemaleHumansIndiaMaleMiddle AgedNeuromyelitis OpticaSequence Homology, Amino AcidAQP4 protein, humanAquaporin 4

Identifiers

PMID33148687
PMCPMC7643530
OpenAlexW3097003771

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.