Trial reportArchives of disease in childhood. Fetal and neonatal edition2021
Two-year outcomes after dextrose gel prophylaxis for neonatal hypoglycaemia.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effectiveness of oral dextrose gel for neonates at risk of hypoglycemia: A systematic review, meta-analysis, and GRADE assessment of randomized controlled trials.Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Oral dextrose gel to prevent hypoglycaemia in at-risk neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Oral dextrose gel to prevent hypoglycaemia in at-risk neonates.The Cochrane database of systematic reviews · 2021Pooled it
- Dextrose gel prophylaxis for neonatal hypoglycaemia and neurocognitive function at early school age: a randomised dosage trial.Archives of disease in childhood. Fetal and neonatal edition · 2024Trial
- Neurocognitive Outcomes at Age 2 Years After Neonatal Hypoglycemia in a Cohort of Participants From the hPOD Randomized Trial.JAMA network open · 2022Trial
- Trial
- Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia (hPOD): A multicenter, double-blind randomized controlled trial.PLoS medicine · 2021Trial
- Measures of neonatal glycemia from blood glucose concentrations and neurodevelopmental outcomes at 2 years.Pediatric research · 2026Article
- Three is Better Than Two: Dose-related Efficacy of Dextrose Gel for Neonatal Hypoglycemia in At-Risk Infants, a Quality Improvement Initiative.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Associations between growth and childhood body composition in very preterm, late preterm and term children.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Exploring the long-term impacts of neonatal hypoglycemia to determine a safe threshold for glucose concentrations.European journal of pediatrics · 2025Review
- Improving blood glucose in late preterm and small for gestational age infants: the use of dextrose 40% gel.Frontiers in pediatrics · 2025Article
- Neonatal dysglycemia: a review of dysglycemia in relation to brain health and neurodevelopmental outcomes.Pediatric research · 2024Review
- Neonatal hypoglycaemia.BMJ medicine · 2024Review
- A quality improvement initiative for neonatal hypoglycemia screening and management in a level III neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Article
- Management of asymptomatic hypoglycemia with 40% oral dextrose gel in near term at-risk infants to reduce intensive care need and promote breastfeeding.Italian journal of pediatrics · 2021Article
- Strategies to improve neurodevelopmental outcomes in babies at risk of neonatal hypoglycaemia.The Lancet. Child & adolescent health · 2021Review
- Clinical Aspects of Neonatal Hypoglycemia: A Mini Review.Frontiers in pediatrics · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveTo determine the effect of prophylactic dextrose gel for prevention of neonatal hypoglycaemia on neurodevelopment and executive function at 2 years' corrected age.
designProspective follow-up of a randomised trial.
settingNew Zealand. PATIENTS: Participants from the pre-hypoglycaemia Prevention with Oral Dextrose (pre-hPOD) trial randomised to one of four dose regimes of buccal 40% dextrose gel or equivolume placebo.
main outcome measuresCoprimary outcomes were neurosensory impairment and executive function. Secondary outcomes were components of the primary outcomes, neurology, anthropometry and health measures.
resultsWe assessed 360 of 401 eligible children (90%) at 2 years' corrected age. There were no differences between dextrose gel dose groups, single or multiple dose groups, or any dextrose and any placebo groups in the risk of neurosensory impairment or low executive function (any dextrose vs any placebo neurosensory impairment: relative risk (RR) 0.77, 95% CI 0.50 to 1.19, p=0.23; low executive function: RR 0.50, 95% CI 0.24 to 1.06, p=0.07). There were also no differences between groups in any secondary outcomes. There was no difference between children who did or did not develop neonatal hypoglycaemia in the risk of neurosensory impairment (RR 1.05, 95% CI 0.68 to 1.64, p=0.81) or low executive function (RR 0.73, 95% CI 0.34 to 1.59, p=0.43).
conclusionProphylactic dextrose gel did not alter neurodevelopment or executive function and had no adverse effects to 2 years' corrected age, but this study was underpowered to detect potentially clinically important effects on neurosensory outcomes.
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