ArticleArchives of disease in childhood. Fetal and neonatal edition2021
Poor postnatal weight growth is a late finding after sepsis in very preterm infants.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of rapid enteral feed advancement with early human milk fortification in very low birth weight preterm infants > 30 weeks gestation in a resource limited setting- a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Defining growth faltering and malnutrition among very preterm infants in a neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Relationship between feeding milestones and comorbidities with the postnatal growth in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Lipidomics Reveals Circulating Lipid Biomarkers for Retinopathy of Prematurity in Preterm Infants.Ophthalmology science · 2026Article
- A Potential Gut-Retina Axis in Retinopathy of Prematurity: Emerging Perspectives on Microbiome-Mediated Modulation of the IGF-1-VEGF Pathway.International journal of molecular sciences · 2026Review
- Early Antibiotic Use and Retinopathy of Prematurity: A Single-Center Retrospective Cohort Study.Ophthalmology science · 2026Article
- Article
- Neonatal Inflammation and Feeding Disorders at 1 Year in Infants With Congenital Gastrointestinal Malformations.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Article
- The influence of interleukin-27 on metabolic fitness in a murine neonatal model of bacterial sepsis.American journal of physiology. Endocrinology and metabolism · 2025Article
- Association of Neonatal Morbidities and Postnatal Growth Faltering in Preterm Neonates.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Prediction of Postnatal Growth Failure in Very Low Birth Weight Infants Using a Machine Learning Model.Diagnostics (Basel, Switzerland) · 2023Article
- Improving the Treatment of Neonatal Sepsis in Resource-Limited Settings: Gaps and Recommendations.Research and reports in tropical medicine · 2023Review
- Review
- Etiology and clinical characteristics of neonatal sepsis in different medical setting models: A retrospective multi-center study.Frontiers in pediatrics · 2022Article
- Investigation Into the Current Situation and Analysis of the Factors Influencing Extrauterine Growth Retardation in Preterm Infants.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo characterise the association between sepsis and postnatal weight growth when accounting for the degree of growth restriction present at birth.
designRetrospective matched cohort study using data from the Postnatal Growth and Retinopathy of Prematurity study. Participants were born with birth weights of <1500 g or gestational ages of <32 weeks between 2006 and 2011 at 29 neonatal centres in the USA and Canada. Sepsis was defined as a culture-confirmed bacterial or fungal infection of the blood or cerebrospinal fluid before 36 weeks' postmenstrual age (PMA). Growth was assessed as the change in weight z-score between birth and 36 weeks' PMA.
resultsOf 4785 eligible infants, 813 (17%) developed sepsis and 693 (85%) were matched 1:1 to controls. Sepsis was associated with a greater decline in weight z-score (mean difference -0.09, 95% CI -0.14 to -0.03). Postnatal weight growth failure (decline in weight z- score>1) was present in 237 (34%) infants with sepsis and 179 (26%) controls (adjusted OR 1.49, 95% CI 1.12 to 1.97). Longitudinal growth trajectories showed similar initial changes in weight z-scores between infants with and without sepsis. By 3 weeks after sepsis onset, there was a greater decline in weight z-scores relative to birth values in those with sepsis than without sepsis (delta z-score -0.89 vs -0.77; mean difference -0.12, 95% CI -0.18 to -0.05). This significant difference persisted until 36 weeks or discharge.
conclusionInfants with sepsis had similar early weight growth trajectories as infants without sepsis but developed significant deficits in weight that were not apparent until several weeks after the onset of sepsis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.