ArticleScience advances2020
Liver-expressed
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Efficacy of Mesenchymal Stem Cell Therapy in Large Animal Models of Acute Liver Failure: A Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Transcriptome changes in leukocytes of dairy calves exposed to heat stress.Translational animal science · 2026Article
- Natural Hepacivirus Infection in Tree Shrews: A Call for Routine Screening in Hepatitis Virus Research.Viruses · 2025Article
- Assessment of hepatitis C virus permissiveness in iteratively genetically humanized mice.Journal of virology · 2025Article
- Receptor transporter protein 4 (RTP4)-mediated repression of hepatitis C virus replication in mouse cells.PLoS pathogens · 2025Article
- Adapted hepatitis C virus clone infects innate immunity-deficient mouse hepatocytes with minimal human HCV entry factors.JHEP reports : innovation in hepatology · 2025Article
- CD302 regulates the malignant phenotypes of lung adenocarcinoma as a tumor suppressor gene.Frontiers in oncology · 2025Article
- TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes.Journal of virology · 2024Article
- Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses.Microbiology spectrum · 2023Article
- Article
- The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection.Journal of virology · 2022Article
- Intra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance.Virus evolution · 2022Article
- Genome Sequences of West Nile Virus Reference Materials.Microbiology resource announcements · 2021Article
- Review
- Review
- Review
- Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements.Journal of virology · 2021Article
- Review
- Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation.Frontiers in immunology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors at 17 institutions in 7 countries.
Richard J P BrownDivision of Veterinary Medicine, Paul Ehrlich Institute, 63225 Langen, Germany. richard.brown@pei.de thomas.pietschmann@twincore.de.ORCID 0000-0002-3292-6671
Birthe TegtmeyerInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.ORCID 0000-0003-3875-0707
Julie SheldonInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Tanvi KheraInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.ORCID 0000-0002-1287-3197
AnggakusumaInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Daniel TodtInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.ORCID 0000-0002-3564-1014
Gabrielle VieyresInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.ORCID 0000-0001-8511-2164
Romy WellerInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Sebastian JoecksInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.ORCID 0000-0003-0248-5374
Yudi ZhangInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Svenja SakeInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Dorothea BankwitzInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Kathrin WelschInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Corinne GinkelInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.ORCID 0000-0002-4876-5681
Michael EngelmannInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Gisa GeroldDepartment of Physiological Chemistry, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany.ORCID 0000-0002-1326-5038
Eike SteinmannInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Qinggong YuanDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.
Michael OttDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.
Florian W R VondranDepartment of General, Visceral, and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany.
Thomas KreyGerman Centre for Infection Research (DZIF), Hannover-Braunschweig Site, Braunschweig, Germany.ORCID 0000-0002-4548-7241
Luisa J StröhInstitute of Virology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-2781-2303
Csaba MiskeyDivision of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.ORCID 0000-0002-7566-9556
Zoltán IvicsDivision of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany.ORCID 0000-0002-7803-6658
Vanessa HerderDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0003-4814-1382
Wolfgang BaumgärtnerDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Chris LauberInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany.
Michael SeifertInstitute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-2844-053X
Alexander W TarrSchool of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.
C Patrick McClureSchool of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0002-1710-1049
Glenn RandallDepartment of Microbiology, The University of Chicago, Chicago, IL 60439, USA.ORCID 0000-0001-7417-3615
Yasmine BaktashInstituto de Biología Integrativa de Sistemas (I2SysBio), Parc Científic de Barcelona, Carrer del Catedràtic Agustín Escardino 9, 46980 Paterna, Valencia, Spain.ORCID 0000-0002-1027-9207
Alexander PlossDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0001-9322-7252
Viet Loan Dao ThiLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-2293-3592
Eleftherios MichailidisSchaller Research Group at Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks, Heidelberg, Germany.ORCID 0000-0002-9907-4346
Mohsan SaeedLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Lieven VerhoyeLaboratory of Liver Infectious Diseases, Ghent University, Ghent, Belgium.
Philip MeulemanLaboratory of Liver Infectious Diseases, Ghent University, Ghent, Belgium.ORCID 0000-0001-6821-234X
Natascha GoedeckeHelmholtz Centre for Infection Research, Division Model Systems for Infection and Immunity, Inhoffenstraße 7, 38124 Braunschweig, Germany.ORCID 0000-0002-6578-6601
Dagmar WirthHelmholtz Centre for Infection Research, Division Model Systems for Infection and Immunity, Inhoffenstraße 7, 38124 Braunschweig, Germany.ORCID 0000-0002-2541-6251
Charles M RiceLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Thomas PietschmannInstitute for Experimental Virology, Centre for Experimental and Clinical Infection Research, Twincore, Feodor-Lynen-Strasse 7, 30625 Hannover, Germany. richard.brown@pei.de thomas.pietschmann@twincore.de.ORCID 0000-0001-6789-4422
Center for Experimental and Clinical Infection Research · DEMedizinische Hochschule Hannover · DEUniversity of Veterinary Medicine Hannover, Foundation · DEGhent University Hospital · BEHeidelberg University · DEPaul Ehrlich Institut · DEUniversity of Nottingham · GBBoston University · USEssen University Hospital · DEHelmholtz Centre for Infection Research · DEInstitute for Integrative Systems Biology · ESLeibniz Institute of Virology (LIV) · DEPrinceton University · USRockefeller University · USUniQure (Netherlands) · NLUniversity Hospital Carl Gustav Carus · DEUniversity of Chicago · US
Funding
Genetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0MHepatitis C Virus Trafficking in HepatocytesR01AI137514 · NIAID · UNIVERSITY OF CHICAGO · PI Glenn C Randall · 2019 to 2026
$2.7MHepatitis C Virus Trafficking in Infected HepatocytesR01AI080703 · NIAID · UNIVERSITY OF CHICAGO · PI RANDALL, GLENN C · 2010 to 2014
$1.7MNIAID NIH HHS R01 AI080703NIAID NIH HHS R01 AI107301NIAID NIH HHS R01 AI137514
Abstract
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barrier determinants limiting infection of rodents, murine liver complementary DNA library screening was performed, identifying transmembrane proteins Cd302 and Cr1l as potent restrictors of HCV propagation. Combined ectopic expression in human hepatoma cells impeded HCV uptake and cooperatively mediated transcriptional dysregulation of a noncanonical program of immunity genes. Murine hepatocyte expression of both factors was constitutive and not interferon inducible, while differences in liver expression and the ability to restrict HCV were observed between the murine orthologs and their human counterparts. Genetic ablation of endogenous
Indexed as
HepacivirusHepatitis CAnimalsMiceMice, TransgenicVirus Internalization
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