ArticleScience advances2020
Reward activity in ventral pallidum tracks satiety-sensitive preference and drives choice behavior.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Ventral pallidal GABAergic neurons control hedonic feeding and obesity.bioRxiv : the preprint server for biology · 2026Article
- POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system.Neuron · 2026Article
- Ventral Pallidum Cholinergic Neurons Respond to Reward and Signal Reward Value.bioRxiv : the preprint server for biology · 2026Article
- Cell type-specific barcoding reveals the single-neuron projectional architecture of the mouse midbrain dopaminergic system.bioRxiv : the preprint server for biology · 2026Article
- Most Ventral Pallidal Cholinergic Neurons Are Bursting Basal Forebrain Cholinergic Neurons with Mesocorticolimbic Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Selective attention to auditory and visual modalities converges onto noncholinergic basal forebrain neurons.Science advances · 2026Article
- Chronic Ethanol Exposure Produces Persistent Impairment in Cognitive Flexibility and Decision Signals in the Striatum.bioRxiv : the preprint server for biology · 2025Article
- Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity.npj metabolic health and disease · 2025Article
- Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution.Science advances · 2024Article
- Article
- Ventral Pallidum and Amygdala Cooperate to Restrain Reward Approach under Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.Nature communications · 2024Article
- Psychostimulants and social behaviors.Frontiers in pharmacology · 2024Review
- Ventral pallidal glutamatergic neurons regulate wakefulness and emotion through separated projections.iScience · 2023Article
- The behavioral signature of stepwise learning strategy in male rats and its neural correlate in the basal forebrain.Nature communications · 2023Article
- Ventral Pallidal GABAergic Neuron Calcium Activity Encodes Cue-Driven Reward Seeking and Persists in the Absence of Reward Delivery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.bioRxiv : the preprint server for biology · 2023Article
- Chronic Semaglutide Treatment in Rats Leads to Daily Excessive Concentration-Dependent Sucrose Intake.Journal of the Endocrine Society · 2023Article
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- Single-neuron projectome of mouse prefrontal cortex.Nature neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A key function of the nervous system is producing adaptive behavior across changing conditions, like physiological state. Although states like thirst and hunger are known to impact decision-making, the neurobiology of this phenomenon has been studied minimally. Here, we tracked evolving preference for sucrose and water as rats proceeded from a thirsty to sated state. As rats shifted from water choices to sucrose choices across the session, the activity of a majority of neurons in the ventral pallidum, a region crucial for reward-related behaviors, closely matched the evolving behavioral preference. The timing of this signal followed the pattern of a reward prediction error, occurring at the cue or the reward depending on when reward identity was revealed. Additionally, optogenetic stimulation of ventral pallidum neurons at the time of reward was able to reverse behavioral preference. Our results suggest that ventral pallidum neurons guide reward-related decisions across changing physiological states.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.