ArticleHormones and behavior2021
Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).
Article in Hormones and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- Serotonergic Modulation of Social Dominance via the Dorsal Raphe-Central Amygdala Circuit in Male Mice.Integrative zoology · 2026Article
- Tissue and Sex-Specific Transcriptomic Signatures Underlying Aggression behavior of Chinese Mitten Crab (Eriocheir sinensis).Marine biotechnology (New York, N.Y.) · 2026Article
- Biomarkers for complex post-traumatic stress disorder: translational and evolutionary perspectives.Frontiers in psychiatry · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Interaction Between Oxytocin and Dopamine Signaling: Focus on the Striatum.International journal of molecular sciences · 2025Review
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- Testosterone differentially modulates the display of agonistic behavior and dominance over opponents before and after adolescence in male Syrian hamsters.Frontiers in behavioral neuroscience · 2025Article
- The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents.Neuroscience and biobehavioral reviews · 2024Review
- Arginine vasopressin in mood disorders: A potential biomarker of disease pathology and a target for pharmacologic intervention.Psychiatry and clinical neurosciences · 2024Review
- Activation of androgen receptor-expressing neurons in the posterior medial amygdala is associated with stress resistance in dominant male hamsters.Hormones and behavior · 2024Article
- Sex-dependent regulation of social avoidance by oxytocin signaling in the ventral tegmental area.Behavioural brain research · 2024Article
- Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys.Biology of sex differences · 2023Article
- Sex differences in dominance relationships in Syrian hamsters.Physiology & behavior · 2023Article
- Dominance status modulates activity in medial amygdala cells with projections to the bed nucleus of the stria terminalis.Behavioural brain research · 2023Article
- Distribution of Vasopressin 1a and Oxytocin Receptor Binding in the Basal Forebrain and Midbrain of Male and Female Mongolian Gerbils.Neuroscience · 2023Article
- Neuroendocrine mechanisms contributing to the coevolution of sociality and communication.Frontiers in neuroendocrinology · 2023Review
- A test of the social behavior network reveals differential patterns of neural responses to social novelty in bonded, but not non-bonded, male prairie voles.Hormones and behavior · 2023Article
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- Sex Differences in Social Cognition.Current topics in behavioral neurosciences · 2023Review
- Sex differences in appetitive and reactive aggression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Dominance status in hamsters is driven by interactions between arginine-vasopressin V1a, oxytocin (OT), and serotonin 1A (5-HT1A) receptors. Activation of V1a and OT receptors in the anterior hypothalamus (AH) increases aggression in males, while decreasing aggression in females. In contrast, activation of 5-HT1A receptors in the AH decreases aggression in males and increases aggression in females. The mechanism underlying these differences is not known. The purpose of this study was to determine if dominance status and sex interact to regulate V1a, OT, and 5-HT1A receptor binding. Same-sex hamsters (N = 47) were paired 12 times across six days in five min sessions. Brains from paired and unpaired (non-social control) hamsters were collected immediately after the last interaction and processed for receptor binding using autoradiography. Differences in V1a, OT, and 5-HT1A receptor binding densities were observed in several brain regions as a function of social status and sex. For example, in the AH, there was an interaction between sex and social status, such that V1a binding in subordinate males was lower than in subordinate females and V1a receptor density in dominant males was higher than in dominant females. There was also an interaction in 5-HT1A receptor binding, such that social pairing increased 5-HT1A binding in the AH of males but decreased 5-HT1A binding in females compared with unpaired controls. These results indicate that dominance status and sex play important roles in shaping the binding profiles of key receptor subtypes across the neural circuitry that regulates social behavior.
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