ArticleBMC public health2020
Increasing trends in incidence of preterm birth among 2.5 million newborns in Guangzhou, China, 2001 to 2016: an age-period-cohort analysis.
Article in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The prevalence of poor sleep quality in the general population in China: a meta-analysis of epidemiological studies.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- The effect of family integrated care on the prognosis of premature infants.BMC pediatrics · 2022Trial
- Analysis of adverse pregnancy outcomes among pregnant women in Hunan Province from 2015 to 2023: Incidence, temporal trends, and risk factors.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Nurse-Driven Quality Indicators for Neonatal Intensive Care: A Delphi Consensus on Family-Integrated Priorities in NICUs.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2026Article
- IL-37 alleviates inflammatory effects and NLRP3 inflammasome activation in LPS-induced preterm birth.Scientific reports · 2026Article
- Steroid hormones in early pregnancy and adverse birth outcomes: a Chinese birth cohort.Frontiers in endocrinology · 2026Article
- Epidemiological characteristics and trends based on a joinpoint regression model of preterm birth with congenital heart disease in Changsha City, China, from 2011 to 2023.Translational pediatrics · 2025Article
- Maternal cobalt concentration and risk of spontaneous preterm birth: the role of fasting blood glucose and lipid profiles.Frontiers in nutrition · 2024Article
- Secular trends of low birth weight, preterm birth, and small for gestational age in Shanghai from 2004 to 2020: an age-period-cohort analysis.BMC pregnancy and childbirth · 2023Article
- Article
- Large-scale characterisation of the pregnancy vaginal microbiome and sialidase activity in a low-risk Chinese population.NPJ biofilms and microbiomes · 2021Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThe incidence of preterm birth (PTB, < 37 weeks of gestation) has been increasing in China and many other countries in recent years. However, the causes of the increase were not well understood. The current study aims to examine the contribution of maternal age, period of delivery, and maternal birth cohorts to long-term trends in preterm birth in Guangzhou, China.
methodsIn a retrospective population-based study, data were obtained from 2,535,000 singleton live births with 20-43 gestational weeks from 2001 to 2016 and recorded in the Guangzhou Perinatal Health Care and Delivery Surveillance System, in China. The age-period-cohort models were applied to investigate the temporal changes in incidences of PTB, stratified by parity.
resultsThe incidence of preterm birth steadily increased from 5.1% in 2001 to 5.9% in 2016, with larger rise in primiparous mothers (from 5.0 to 5.9%) compared to multiparous mothers (from 5.6 to 5.9%). A J-shaped and a V-shaped relationship were found between maternal age and PTB among primiparous and multiparous mothers, respectively. A linear cohort effect was found among primiparous mothers with the lowest risk of PTB [risk ratio (RR) = 0.81, 95% confidence interval (CI): 0.74 to 0.89] in 1961 and the highest risk (RR = 1.06, 95% CI: 1.00 to 1.13) in 1997 compared to the mothers born in 1981. An inverse U-shaped association between maternal birth cohort and PTB was found in multiparous mothers. There were weak decreasing period effects on the trend of overall PTB among multiparous mothers and on the trend of extremely (< 27 weeks) or very (28-31 weeks) PTB among both parity groups during the period of 2001-2012.
conclusionsOur findings showed the PTB incidences had been increasing in the past 16 years in Guangzhou, China and both maternal age and cohort effects contributed to these trends. Further studies are recommended on the impact of altered maternal age and parity on premature births and corresponding public education and public health policies.
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