SynthesisBMC cardiovascular disorders2020
Diabetic retinopathy predicts cardiovascular mortality in diabetes: a meta-analysis.
Synthesis in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Elevated serum lipoprotein(a) levels as a potential risk factor for diabetic retinopathy in type 2 diabetes: a meta-analysis.International ophthalmology · 2024Pooled it
- Associations between diabetic retinopathy, mortality, disease, and mental health: an umbrella review of observational meta-analyses.BMC endocrine disorders · 2022Pooled it
- Scalable discovery and validation of order-specific electronic health record event trajectories for interpretable adverse-outcome risk estimation.Journal of biomedical informatics · 2026Article
- Recent Investigations on Pathogenesis, Biomarkers, Epigenetics, and Emerging Therapeutic Strategies to Modulate Multiple Signaling Pathways in Diabetic Retinopathy.Journal of ophthalmology · 2026Review
- Interpreting Deep Neural Networks in Diabetic Retinopathy Grading: A Comparison with Human Decision Criteria.Life (Basel, Switzerland) · 2025Article
- Dissecting the relationship between heart failure and diabetic retinopathy severity in patients with diabetes and chronic kidney disease: an observational cohort study.Scientific reports · 2025Observational
- Cardiovascular outcomes of SGLT-2 inhibitors' subtypes in type 2 diabetes; an updated systematic review and meta-analysis of randomized controlled trials.Journal of diabetes and metabolic disorders · 2025Review
- Medication time of metformin and sulfonylureas and incidence of cardiovascular diseases and mortality in type 2 diabetes: a pooled cohort analysis.Scientific reports · 2025Article
- Multiple long-term conditions as the next transition in the global diabetes epidemic.Communications medicine · 2025Review
- Diabetic retinopathy further increases risk of cardiovascular disease mortality in a high-risk cohort.Scientific reports · 2025Article
- Article
- Non-ocular biomarkers for early diagnosis of diabetic retinopathy by non-invasive methods.Frontiers in endocrinology · 2025Review
- Prediction of heart failure risk factors from retinal optical imaging via explainable machine learning.Frontiers in medicine · 2025Article
- Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data.Journal of clinical medicine · 2024Article
- Unseen threat: how subclinical atherosclerosis increases mortality risk in patients with type 1 diabetes.Cardiovascular diabetology · 2024Observational
- Characteristics of ocular injuries associated with mortality in patients admitted with major trauma.BMC ophthalmology · 2024Article
- The prevention opportunities of retinopathy in diabetic patients - position paper endorsed by the Polish Lipid Association.Archives of medical science : AMS · 2024Article
- Use of digital retinography to detect vascular changes in pre-diabetic patients: a cross-sectional study.Diabetology & metabolic syndrome · 2023Article
- Pragmatic clinic-based investigation of echocardiogram parameters in asymptomatic patients with type 2 diabetes in routine clinical practice and its association with suggestive coronary artery disease: a pilot study.Diabetology & metabolic syndrome · 2023Article
- Risk Factors for Recurrent Vitreous Hemorrhage in Type 2 Diabetes Mellitus Patients after Posterior Vitrectomy.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe prognostic significance of diabetic retinopathy (DR) for cardiovascular diseases (CVD) remained unclear. Therefore, we performed this meta-analysis to assess whether DR predicted CVD mortality in diabetic patients.
methodsWe searched PubMed, Embase, Web of Science and Cochrane Library for cohort studies reporting the association of DR and CVD mortality. Then we pooled the data for analysis.
resultsAfter screening the literature, 10 eligible studies with 11,239 diabetic subjects were finally included in quantitative synthesis. The pooled risk ratio (RR) of DR, mild DR, and severe DR for CVD mortality was 1.83 (95% confidence interval (CI): 1.42, 2.36; p < 0.001), 1.13 (95% CI 0.81, 1.59; p = 0.46), and 2.26 (1.31, 3.91; p = 0.003), respectively, compared to those without DR. In type 2 DM, the patients with DR had a significantly higher CVD mortality (RR: 1.69; 95% CI 1.27, 2.24; p < 0.001). Subgroup analysis also showed a significantly higher CVD mortality in DR according to various regions, study design, data source, and follow-up period (all RR > 1; all P values < 0.05). Data from 2 studies showed no significant correlation of DR and CVD mortality in diabetic patients receiving cardiovascular surgery (RR: 2.40; 95% CI 0.63, 9.18; P = 0.200).
conclusionsDR is a risk marker of cardiovascular death, and severe DR predicts a doubled mortality of CVD in diabetes. These findings indicate the importance of early identification and management of diabetic patients with DR to reduce the risk of death.
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