Evidence map›Paper›PMID 33148163›Full record

ArticleThe journal of physiological sciences : JPS2020

The distribution of eukaryotic initiation factor 4E after bouts of resistance exercise is altered by shortening of recovery periods.

Junya Takegaki, Riki Ogasawara, Karina Kouzaki, Satoshi Fujita, Koichi Nakazato, Naokata Ishii

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Junya TakegakiDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan. takegaki@fc.ritsumei.ac.jp.ORCID http://orcid.org/0000-0002-3398-5833
Riki OgasawaraDepartment of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan.ORCID http://orcid.org/0000-0002-2600-1613
Karina KouzakiGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
Satoshi FujitaFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Koichi NakazatoGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
Naokata IshiiDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Nippon Sport Science University · JPRitsumeikan University · JPNagoya Institute of Technology · JPTokyo University of the Arts · JP

Funding

Japan Society for the Promotion of Science 17H08183Japan Society for the Promotion of Science 18H06450Japan Society for the Promotion of Science JP15H03078
6 · The paper itself

Abstract

Insufficient duration of recovery between resistance exercise bouts reduces the effects of exercise training, but the influence on muscle anabolic responses is not fully understood. Here, we investigated the changes in the distribution of eukaryotic initiation factor (eIF) 4E, a key regulator of translation initiation, and related factors in mouse skeletal muscle after three successive bouts of resistance exercise with three durations of recovery periods (72 h: conventional, 24 h: shorter, and 8 h: excessively shorter). Bouts of resistance exercise dissociated eIF4E from eIF4E binding protein 1, with the magnitude increasing with shorter recovery. Whereas bouts of resistance exercise with 72 h recovery increased the association of eIF4E and eIF4G, those with shorter recovery did not. Similar results were observed in muscle protein synthesis. These results suggest that insufficient recovery inhibited the association of eIF4E and eIF4G, which might cause attenuation of protein synthesis activation after bouts of resistance exercise.

Indexed as

Physical Conditioning, AnimalResistance TrainingAnimalsEukaryotic Initiation Factor-4EMaleMiceMice, Inbred C57BLMuscle ProteinsMuscle, SkeletalPhosphoproteinsPhosphorylationRecovery of FunctioneIF4E protein, mouseEukaryotic Initiation Factor-4EMuscle ProteinsPhosphoproteinsProtein synthesisRecoveryResistance exerciseSkeletal muscleTranslation initiation complex

Identifiers

PMID33148163
PMCPMC10717013
OpenAlexW3096003123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.