Evidence map›Paper›PMID 33147894›Full record

ArticleNutrients2020

Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study.

Gaëlle Annweiler, Mathieu Corvaisier, Jennifer Gautier, Vincent Dubée, Erick Legrand, Guillaume Sacco, Cédric Annweiler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 24 pooled it
32.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 24 syntheses or guidelines pooled it, 260 citations in OpenAlex.

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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Gaëlle AnnweilerSchool of Medicine, Health Faculty, University of Angers, 49035 Angers, France.
Mathieu CorvaisierDepartment of Geriatric Medicine, Research Center on Autonomy and Longevity, University Hospital, Angers, France.
Jennifer GautierDepartment of Geriatric Medicine, Research Center on Autonomy and Longevity, University Hospital, Angers, France.
Vincent DubéeSchool of Medicine, Health Faculty, University of Angers, 49035 Angers, France.
Erick LegrandSchool of Medicine, Health Faculty, University of Angers, 49035 Angers, France.
Guillaume SaccoDepartment of Geriatric Medicine, Research Center on Autonomy and Longevity, University Hospital, Angers, France.
Cédric AnnweilerSchool of Medicine, Health Faculty, University of Angers, 49035 Angers, France.
Université d'Angers · FRInserm · FRLaboratoire de Psychologie des Pays de la Loire · FRLaboratoires d'Anjou (France) · FRWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this quasi-experimental study was to determine whether bolus vitamin D supplementation taken either regularly over the preceding year or after the diagnosis of COVID-19 was effective in improving survival among hospitalized frail elderly COVID-19 patients.

methodsSeventy-seven patients consecutively hospitalized for COVID-19 in a geriatric unit were included. Intervention groups were participants regularly supplemented with vitamin D over the preceding year (Group 1), and those supplemented with vitamin D after COVID-19 diagnosis (Group 2). The comparator group involved participants having received no vitamin D supplements (Group 3). Outcomes were 14-day mortality and highest (worst) score on the ordinal scale for clinical improvement (OSCI) measured during COVID-19 acute phase. Potential confounders were age, gender, functional abilities, undernutrition, cancer, hypertension, cardiomyopathy, glycated hemoglobin, number of acute health issues at admission, hospital use of antibiotics, corticosteroids, and pharmacological treatments of respiratory disorders.

resultsThe three groups (

conclusionsRegular bolus vitamin D supplementation was associated with less severe COVID-19 and better survival in frail elderly.

Indexed as

Dietary SupplementsAged, 80 and overBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentFemaleFrail ElderlyFrailtyHospitalizationHumansMaleNon-Randomized Controlled Trials as TopicPandemicsPneumonia, ViralSARS-CoV-2Vitamin DVitaminsCOVID-19older adultsquasi-experimental studySARS-CoV-2therapeuticsvitamin D

Identifiers

PMID33147894
PMCPMC7693938
OpenAlexW3094931890

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.