Evidence map›Paper›PMID 33147808›Full record

ArticleChildren (Basel, Switzerland)2020

Diagnosis and Treatment of Chronic Neuropathic and Mixed Pain in Children and Adolescents: Results of a Survey Study amongst Practitioners.

Thomas G de Leeuw, Tjitske van der Zanden, Simona Ravera, Mariagrazia Felisi, Donato Bonifazi, Dick Tibboel, Adriana Ceci, Florentia Kaguelidou, Saskia N de Wildt, On Behalf Of The Gapp Consortium

Open access · goldAbstract read
In one paragraph

Article in Children (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Thomas G de LeeuwDepartment of Pediatric Anesthesia and Pain Medicine, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-9516-3088
Tjitske van der ZandenIntensive Care and Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Simona RaveraPharmaceutical Research Management Srl, Via Luigi Porta 14, 27100 Pavia, Italy.
Mariagrazia FelisiPharmaceutical Research Management Srl, Via Luigi Porta 14, 27100 Pavia, Italy.
Donato BonifaziConsorzio per Valutazioni Biologiche e Farmacologiche, Via Putignani 178, 70122 Bari, Italy.
Dick TibboelIntensive Care and Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Adriana CeciFondazione per la Ricerca Farmacologica Gianni Benzi onlus, Via Abate Eustasio 30, 70010 Valenzano, Italy.
Florentia KaguelidouCentre d'Investigations Cliniques, INSERM CIC1426, Hôpital Robert Debré, APHP, Université de Paris, UMR-1123 ECEVE, 75019 Paris, France.
Saskia N de WildtIntensive Care and Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-0502-0647
On Behalf Of The Gapp Consortium
Erasmus MC - Sophia Children’s Hospital · NLPHARM (Italy) · ITConsorzio per Valutazioni Biologiche e Farmacologiche · ITGianni Benzi Pharmacological Research Foundation · ITInserm · FRRadboud University Nijmegen · NL

Funding

Seventh Framework Programme No 602962
6 · The paper itself

Abstract

Validated diagnostic tools to diagnose chronic neuropathic and mixed pain in children are missing. Therapeutic options are often derived from therapeutics for adults. To investigate the international practice amongst practitioners for the diagnosis and treatment of chronic, neuropathic pain in children and adolescents, we performed a survey study among members of learned societies or groups whose members are known to treat pediatric pain. The survey included questions concerning practitioners and practice characteristics, assessment and diagnosis, treatment and medication. We analyzed 117 returned questionnaires, of which 41 (35%) were fully completed and 76 (65%) were partially completed. Most respondents based the diagnosis of neuropathic pain on physical examination (68 (58.1%)), patient history (67 (57.3%)), and underlying disease (59 (50.4%)) combined. Gabapentin, amitriptyline, and pregabalin were the first-choice treatments for moderate neuropathic pain. Tramadol, ibuprofen, amitriptyline, and paracetamol were the first-choice treatments for moderate mixed pain. Consensus on the diagnostic process of neuropathic pain in children and adolescents is lacking. Drug treatment varies widely for moderate, severe neuropathic, and mixed pain. Hence, diagnostic tools and therapy need to be harmonized and validated for use in children.

Indexed as

childrenchronicdiagnosismixed painneuropathic painpractitionerstreatment

Identifiers

PMID33147808
PMCPMC7694093
OpenAlexW3097166842

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.