ArticleCell metabolism2020
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway.
Open access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 149 citations in OpenAlex.
- Structural and functional impact of cystic fibrosis on endocrine pancreatic innervation.Clinical science (London, England : 1979) · 2026Article
- The comparative cell physiology of stem cell-derived and primary human β cells.Nature reviews. Endocrinology · 2026Review
- iG6PSnFR: A genetically encoded fluorescent sensor for observing glucose-6-phosphate dynamics in living preparations.bioRxiv : the preprint server for biology · 2026Article
- GABA Regulates CaMetabolites · 2026Article
- Compartmentalized Nutrient and Hormone Sensing in β-Cells: the Role of Primary Cilia.Physiology (Bethesda, Md.) · 2026Review
- Compartmentalized glycolysis powers ATP production in primary cilia and engages mitochondria via the phosphoenolpyruvate cycle.bioRxiv : the preprint server for biology · 2026Article
- The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging.Nature aging · 2026Article
- Mitochondrial control of glycerolipid synthesis by a PEP shuttle.bioRxiv : the preprint server for biology · 2026Article
- Article
- Modelling the effects of human SUR1 R1420H variation on insulin secretory function using isogenic iPSC-derived pancreatic islets.Diabetologia · 2026Article
- The Dual Anaplerotic Model (DAM): Integral Roles of Pyruvate Carboxylase and the GABA Shunt in Beta Cell Insulin Secretion.Life (Basel, Switzerland) · 2026Article
- Glycolytic activation of β-cell NaMolecular metabolism · 2026Article
- Review
- Phospho-enol pyruvate carboxykinase inhibition limits effector function in inflammatory T cells.Frontiers in immunology · 2026Article
- Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism.Nature communications · 2025Article
- Fructose and insulin: A sweet sabotage hypothesis?Endocrine · 2025Review
- Measuring mitochondrial membrane potential.The EMBO journal · 2025Article
- The effects of free fatty acid-free bovine serum albumin and palmitate on pancreatic β-cell function.Islets · 2025Article
- β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies.Cells · 2025Review
- Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication.Cell metabolism · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
19 authors at 6 institutions in 1 country.
Sophie L LewandowskiDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Rebecca L CardoneDepartment of Internal Medicine, Yale University, New Haven, CT 06520, USA.
Hannah R FosterDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Thuong HoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Evgeniy PotapenkoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Chetan PoudelDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Halena R VanDeusenDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Sophia M SdaoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Tiago C AlvesDepartment of Internal Medicine, Yale University, New Haven, CT 06520, USA.
Xiaojian ZhaoDepartment of Internal Medicine, Yale University, New Haven, CT 06520, USA.
Megan E CapozziDuke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
Arnaldo H de SouzaDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Ishrat JahanDepartment of Biomedical Sciences, Ohio University, Athens, OH 45701, USA.
Craig J ThomasNational Center for Advancing Translational Sciences, Rockville, MD 20850, USA.
Craig S NunemakerDepartment of Biomedical Sciences, Ohio University, Athens, OH 45701, USA.
Dawn Belt DavisDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Jonathan E CampbellDuke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
Richard G KibbeyDepartment of Internal Medicine, Yale University, New Haven, CT 06520, USA; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06520, USA. Electronic address: richard.kibbey@yale.edu.
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. Electronic address: mmerrins@medicine.wisc.edu.
University of Wisconsin–Madison · USYale University · USDuke University · USOhio University · USNational Center for Advancing Translational Sciences · USWilliam S. Middleton Memorial Veterans Hospital · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0MBiology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9MTRAINING IN NUTRITIONT32DK007665 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GUY E GROBLEWSKI, Chi- Liang Eric Yen · 1993 to 2026
$9.2MMitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MERRINS, MATTHEW J. · 2021 to 2025
$3.4MMetabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta CellsR01DK113103 · NIDDK · YALE UNIVERSITY · PI Matthew J. Merrins · 2017 to 2026
$3.3MThe role of GLP-1 and CCK in the pancreatic islet to promote beta-cell survivalR01DK110324 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIS, DAWN B · 2016 to 2020
$2.0MComparative analysis of geroprotective interventions in established and novel mouse models of Alzheimer's diseaseR01AG062328 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM, MERRINS, MATTHEW J. · 2018 to 2022
$2.0MThe role of the mitochondrial GTP cycle in insulin secretionR01DK092606 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G · 2011 to 2015
$1.8MChastening the double-edged sword of glucose metabolism in beta-cellsR01DK110181 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G · 2016 to 2019
$1.7MCharacterization of Mitochondrial GTP as an Intramitochondrial Metabolic SignalK08DK080142 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G · 2008 to 2012
$763kBLRD VA I01 BX004715NCATS NIH HHS UL1 TR001863NCRR NIH HHS UL1 RR024139NIA NIH HHS R01 AG062328NIA NIH HHS R21 AG050135NIA NIH HHS T32 AG000213NIDDK NIH HHS F31 DK126403NIDDK NIH HHS F32 DK116542NIDDK NIH HHS K01 DK101683NIDDK NIH HHS K08 DK080142NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK092606NIDDK NIH HHS R01 DK110181NIDDK NIH HHS R01 DK110324NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01 DK127637NIDDK NIH HHS T32 DK007665
Abstract
Pancreatic β cells couple nutrient metabolism with appropriate insulin secretion. Here, we show that pyruvate kinase (PK), which converts ADP and phosphoenolpyruvate (PEP) into ATP and pyruvate, underlies β cell sensing of both glycolytic and mitochondrial fuels. Plasma membrane-localized PK is sufficient to close K
Indexed as
AnimalsCell LineHumansInsulinInsulin SecretionMaleMiceMice, Inbred C57BLPyruvate KinaseInsulinPyruvate Kinaseanaplerosisbiosensor imaginginsulin secretionK(ATP) channelmetabolic fluxmetabolic oscillationsoxidative phosphorylationphosphoenolpyruvate cyclepyruvate kinaseβ cell metabolism
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.