Evidence map›Paper›PMID 33147481›Full record

ArticleCell metabolism2020

A Selective Sweep Conceals a MicroRNA with Broad Metabolic Effects.

Iain Mathieson, Struan F A Grant

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Iain MathiesonDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: mathi@pennmedicine.upenn.edu.
Struan F A GrantDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Divisions of Genetics and Endocrinology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: grants@email.chop.edu.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Genome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5M
Functional Interrogation of T2D-associated genes in human stem cell-derived models and miceUM1DK126194 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GRANT, STRUAN F A, KAESTNER, KLAUS H · 2020 to 2024
$8.8M
Elucidation of Genetic Effects on Sleep and Circadian TraitsR01HL143790 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GEHRMAN, PHILIP RICHARD, GRANT, STRUAN F A · 2018 to 2021
$3.6M
Polygenic prediction and evolution of complex traitsR35GM133708 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Iain Neil Mathieson · 2019 to 2026
$2.9M
NHLBI NIH HHS R01 HL143790NICHD NIH HHS R01 HD056465NIDDK NIH HHS UM1 DK126194NIGMS NIH HHS R35 GM133708
6 · The paper itself

Abstract

The need for discovering new genes driving metabolic disease susceptibility is clear; even clearer is the need for their subsequent functional characterization. A new paper reports a role for miR-128-1 in metabolic control through a series of elegant mouse studies, and an intriguing hypothesis about its "thrifty" role in metabolism.

Indexed as

Metabolic DiseasesMicroRNAsAnimalsHumansMiceMicroRNAs

Identifiers

PMID33147481
OpenAlexW3097237407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.