Evidence map›Paper›PMID 33147447›Full record

ReviewJournal of molecular and cellular cardiology2021

Calcium influx through the mitochondrial calcium uniporter holocomplex, MCU

Liron Boyman, Maura Greiser, W Jonathan Lederer

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Intracellular CaBiologia futura · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Cytosolic CaBiophysical reports · 2023
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. CaCells · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Liron BoymanCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA; The Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: LBoyman@som.umaryland.edu.
Maura GreiserCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA; The Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
W Jonathan LedererCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA; The Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: jlederer@som.umaryland.edu.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Exploring the Molecular Physiology of Atrial FibrillationR01HL140934 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, MARX, STEVEN O · 2018 to 2025
$6.0M
Multiscale spatiotemporal modeling of cardiac mitochondriaU01HL116321 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAFRI, MOHSIN SALEET, LEDERER, WILLIAM JONATHAN · 2014 to 2018
$3.5M
Chemo-mechanical signaling in atrial myocytesR01HL142290 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN, WARD, CHRISTOPHER WILLIAM · 2019 to 2022
$2.6M
Microtubule Regulated Mechanotransduction in Skeletal MuscleR01AR071618 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WARD, CHRISTOPHER WILLIAM · 2017 to 2021
$2.6M
NHLBI NIH HHS R01 HL140934NHLBI NIH HHS R01 HL142290NHLBI NIH HHS U01 HL116321NIAMS NIH HHS R01 AR071618NIA NIH HHS P30 AG028747
6 · The paper itself

Abstract

Ca

Indexed as

AnimalsBiological TransportBiophysical PhenomenaCalciumCalcium ChannelsHumansMitochondriaMitochondrial Permeability Transition PoreCalciumCalcium Channelsmitochondrial calcium uniporterMitochondrial Permeability Transition PoreHeartMitochondrial Ca2+ signalingMitochondrial calcium uniporter complex (MCUcx)Mitochondrial Na+/Ca2+ exchanger (NCLX)Mitochondrial permeability transition pore (mPTP)Skeletal muscle

Identifiers

PMID33147447
PMCPMC7880866

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.