Evidence map›Paper›PMID 33147410›Full record

ArticleJournal of medicinal chemistry2020

Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine

Jian Lu, Aaron G Bart, Qian Wu, Kevin R Criscione, Michael J McLeish, Emily E Scott, Gary L Grunewald

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Effects of a Synthetic Isoquinoline Derivative AgainstPathogens (Basel, Switzerland) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jian LuDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
Aaron G BartDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
Qian WuDepartment of Chemistry and Chemical Biology, Purdue School of Science, IUPUI, Indianapolis, Indiana 46202, United States.
Kevin R CriscioneDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0001-8429-3696
Michael J McLeishDepartment of Chemistry and Chemical Biology, Purdue School of Science, IUPUI, Indianapolis, Indiana 46202, United States.ORCID 0000-0002-9221-9119
Emily E ScottDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
Gary L GrunewaldDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0003-1297-7436
University of Kansas · USIndiana University – Purdue University Indianapolis · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
TRAFFICKING OF THE PLASMA MEMBRANE CA2+-ATPASE TO RAFTSP20RR017708 · NCRR · UNIVERSITY OF KANSAS LAWRENCE · PI FISCHER, CHRISTOPHER JAMES · 2002 to 2011
$20.1M
DESIGN OF INHIBITORS OF EPINEPHRINE BIOSYNTHESISR01HL034193 · NHLBI · UNIVERSITY OF KANSAS LAWRENCE · PI GRUNEWALD, GARY L · 1985 to 2005
$2.7M
NCRR NIH HHS P20 RR017708NHLBI NIH HHS R01 HL034193NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

The enzyme phenylethanolamine

Indexed as

Drug DesignAdenosineBinding SitesCrystallography, X-RayEnzyme InhibitorsHumansIsoquinolinesModels, MolecularPhenylethanolamine N-MethyltransferaseProtein DomainsS-AdenosylmethionineStructure-Activity RelationshipAdenosineEnzyme InhibitorsIsoquinolinesPhenylethanolamine N-MethyltransferaseS-Adenosylmethionine

Identifiers

PMID33147410
PMCPMC9052873
OpenAlexW3097328837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.