ArticleEuropean child & adolescent psychiatry2022
Subgrouping children and adolescents with disruptive behaviors: symptom profiles and the role of callous-unemotional traits.
Article in European child & adolescent psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 14 citations in OpenAlex.
- Exploring Transdiagnostic Mechanisms of Youth Externalizing Psychopathology: A Longitudinal Person-Centered Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Child and parent behavioral and physiological reactivity to threat and distress predict children's proactive and reactive aggression.Frontiers in child and adolescent psychiatry · 2026Article
- Prefrontal cortex structural and developmental associations with callous-unemotional traits and aggression.Scientific reports · 2024Article
- Emotion recognition profiles in clusters of youth based on levels of callous-unemotional traits and reactive and proactive aggression.European child & adolescent psychiatry · 2023Article
- Article
- Child Neuropsychological Functioning and Interpersonal Callousness as Predictors of Externalising Behaviour in Early Adolescence: A Prospective Population-based Study.Research on child and adolescent psychopathology · 2023Article
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Authors and funding
23 authors at 9 institutions in 5 countries.
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Abstract
Disruptive behavior during childhood and adolescence is heterogeneous and associated with several psychiatric disorders. The identification of more homogeneous subgroups might help identify different underlying pathways and tailor treatment strategies. Children and adolescents (aged 8-18) with disruptive behaviors (N = 121) and healthy controls (N = 100) were included in a European multi-center cognition and brain imaging study. They were assessed via a battery of standardized semi-structured interviews and questionnaires. K-means cluster-model analysis was carried out to identify subgroups within the group with disruptive behaviors, based on clinical symptom profiles, callous-unemotional (CU) traits, and proactive and reactive aggression. The resulting subgroups were then compared to healthy controls with regard to these clinical variables. Three distinct subgroups were found within the group with disruptive behaviors. The High CU Traits subgroup presented elevated scores for CU traits, proactive aggression and conduct disorder (CD) symptoms, as well as a higher proportion of comorbidities (CD + oppositional defiant disorder + attention deficit hyperactivity disorder (ADHD). The ADHD and Affective Dysregulation subgroup showed elevated scores for internalizing and ADHD symptoms, as well as a higher proportion of females. The Low Severity subgroup had relatively low levels of psychopathology and aggressive behavior compared to the other two subgroups. The High CU Traits subgroup displayed more antisocial behaviors than the Low Severity subgroup, but did not differ when compared to the ADHD and Affective Dysregulation subgroup. All three subgroups differed significantly from the healthy controls in all the variables analyzed. The present study extends previous findings on subgrouping children and adolescents with disruptive behaviors using a multidimensional approach and describes levels of anxiety, affective problems, ADHD, proactive aggression and CU traits as key factors that differentiate conclusively between subgroups.
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