Evidence map›Paper›PMID 33147250›Full record

ArticlePloS one2020

Understanding patient transfers across multiple clinics in Zambia among HIV infected adults.

Kombatende Sikombe, Aaloke Mody, Jillian Kadota, Jesse Jake Pry, Sandra Simbeza, Ingrid Eshun-Wilson, Sitali Richard Situmbeko, Chama Bukankala, Laura Beres, Njekwa Mukamba and 5 more

Registry-linked trialAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06803316 (Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care After Treatment Lapses in Zambia), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06803316 completednot on this mapstarted 2022, after this paper: background citation

Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care After Treatment Lapses in Zambia

Typeobservational_patient_registrySponsorCentre for Infectious Disease Research in ZambiaRan2022 to 2025Enrolled658ConditionsHIV Antiretroviral Therapy (ART) Adherence
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  5. Incidence of Health Facility Switching and Associations With HIV Viral Rebound Among Persons on Antiretroviral Therapy in Uganda: A Population-based Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
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  7. Article
  8. Article
  9. Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kombatende SikombeResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.ORCID 0000-0002-8187-8661
Aaloke ModyDivision of Infectious Diseases, Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America.ORCID 0000-0003-3787-365X
Jillian KadotaDivision of Pulmonary and Critical Care Medicine and Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America.
Jesse Jake PryResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.ORCID 0000-0001-6312-4420
Sandra SimbezaResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Ingrid Eshun-WilsonDivision of Infectious Diseases, Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America.
Sitali Richard SitumbekoResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Chama BukankalaResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Laura BeresDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Njekwa MukambaResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Mwanza Wa MwanzaResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Carolyn Bolton-MooreResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Charles B HolmesResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Elvin H GengDivision of Infectious Diseases, Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America.
Izukanji SikazweResearch Department, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
MENTORING MULTIDISCIPLINARY PATIENT-ORIENTED RESEARCH IN ENGAGEMENT IN HIV CAREK24AI134413 · NIAID · WASHINGTON UNIVERSITY · PI Elvin H. Geng · 2017 to 2026
$1.4M
NIAID NIH HHS K24 AI134413NIAID NIH HHS P30 AI027763
6 · The paper itself

Abstract

Many patients in HIV care in Africa considered lost to follow up (LTFU) at one facility are reportedly accessing care in another. The success of these unofficial transfers as measured by time to re-entry at the new-facility, prevalence of treatment interruptions, speed of ART-initiation, and overall continuity of care is not well characterized but may reveal opportunities for improvement. We traced a random sample of LTFU HIV-infected patients in Zambia. Among those found alive and reported in care at a new-facility, we reviewed records at the receiving facility to verify transfer; and when verified, documented the transfer experience. We used Kaplan-Meier methods to examine incidence of ART-initiation after transfer to new clinic. We assessed demographic and clinical characteristics, official and cross-provincial transfer for associations with HIV treatment re-engagement using Poisson regression models and associations between official-transfer and same-day ART initiation at the new-facility. Among 350 LTFU-patients, 178 (51%) were successfully verified through chart review at the new-facility. 132 (74.2%) were female, 72 (40.4%) aged 25-35, and 51% were ever recorded as previously being on ART. 110 patients (61.8%) were registered under new ART-IDs and 97 (54.5%) received a new HIV test. 54% of those previously on ART-initiated on the same-day. Using the same ART-ID was associated with same-day initiation compared to those receiving a new ART-ID (p = 0.07). 80% (n = 91) of those ever on ART had evidence of medication initiation at new clinic. Among these, initiation reached 66% (95% CI: 56-75) by 30 days, 77.5% (95% CI: 68-86) by 90 days after new-facility presentation. Many patients use new identifiers at new facilities, indicative of inefficiencies. Re-entry into new facilities among the unofficial-transfer population is often delayed and timely treatment initiation is inconsistent, suggesting interruptions in treatment. Health systems innovations to ensure smooth and safe transfers are needed to maintain quality HIV care.

Indexed as

Patient TransferAdultAntiretroviral Therapy, Highly ActiveFemaleGeographyHIV InfectionsHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisTime FactorsZambia

Identifiers

PMID33147250
PMCPMC7641414

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.