Evidence map›Paper›PMID 33147198›Full record

ArticleJournal of synchrotron radiation2020

3D virtual histology of human pancreatic tissue by multiscale phase-contrast X-ray tomography.

Jasper Frohn, Diana Pinkert-Leetsch, Jeannine Missbach-Güntner, Marius Reichardt, Markus Osterhoff, Frauke Alves, Tim Salditt

Open access · hybridAbstract read
In one paragraph

Article in Journal of synchrotron radiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jasper FrohnInstitute for X-ray Physics, Universität Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.
Diana Pinkert-LeetschInstitute of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Robert Koch Strasse 40, 37075 Göttingen, Germany.
Jeannine Missbach-GüntnerInstitute of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Robert Koch Strasse 40, 37075 Göttingen, Germany.
Marius ReichardtInstitute for X-ray Physics, Universität Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.
Markus OsterhoffInstitute for X-ray Physics, Universität Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.ORCID 0000-0002-7865-515X
Frauke AlvesInstitute of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Robert Koch Strasse 40, 37075 Göttingen, Germany.
Tim SaldittInstitute for X-ray Physics, Universität Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.ORCID 0000-0003-4636-0813
Universitätsmedizin Göttingen · DE

Funding

Bundesministerium für Bildung und Forschung 05K19MG2Deutsche Forschungsgemeinschaft EXC2067
6 · The paper itself

Abstract

A multiscale three-dimensional (3D) virtual histology approach is presented, based on two configurations of propagation phase-contrast X-ray tomography, which have been implemented in close proximity at the GINIX endstation at the beamline P10/PETRA III (DESY, Hamburg, Germany). This enables the 3D reconstruction of characteristic morphological features of human pancreatic normal and tumor tissue, as obtained from cancer surgery, first in the form of a large-scale overview by parallel-beam illumination, followed by a zoom into a region-of-interest based on zoom tomography using a Kirkpatrick-Baez mirror with additional waveguide optics. To this end 1 mm punch biopsies of the tissue were taken. In the parallel tomography, a volumetric throughput on the order of 0.01 mm

Indexed as

User-Computer InterfaceAnisotropyBiopsyHumansImaging, Three-DimensionalMicroscopy, Phase-ContrastPancreasPancreatic NeoplasmsProof of Concept StudyTomography, X-Ray Computed3D histologybiopsypancreasphase retrievalX-ray tomography

Identifiers

PMID33147198
PMCPMC7642968
OpenAlexW3095427844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.