Evidence map›Paper›PMID 33146412›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2021

Using apheresis-derived cells to augment microdrilling in the treatment of chondral defects in an ovine model.

Frances Henson, Helen Lydon, Mark Birch, Roger Brooks, Andrew McCaskie

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Frances HensonDivision of Trauma and Orthopaedic Surgery, Department of Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3518-1492
Helen LydonDivision of Trauma and Orthopaedic Surgery, Department of Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4012-7631
Mark BirchDivision of Trauma and Orthopaedic Surgery, Department of Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Roger BrooksDivision of Trauma and Orthopaedic Surgery, Department of Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Andrew McCaskieDivision of Trauma and Orthopaedic Surgery, Department of Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6476-0832

Funding

Medical Research Council MR/K017047/1Medical Research Council MR/R015635/1Versus Arthritis 19429Versus Arthritis REAG 183
6 · The paper itself

Abstract

The treatment of chondral defects using microdrilling often results in a mechanically weak fibrocartilagenous repair, rather than a more robust hyaline cartilage repair. Many different microfracture/microdrilling augmentation techniques have been described, including the use of cellular products to enhance healing. Autologous peripheral blood progenitor cells can be obtained via apheresis after administration of granulocyte colony-stimulating factor (G-CSF) and have been used successfully to augment microdrilling in clinical patients. The objective of this study was to use apheresis-derived mononuclear blood cells to augment microdrilling treatment of a cartilage defect in an ovine model to determine the effect on healing. Forty adult female sheep were used in this study and were divided into a control group (microdrilling alone) and a treatment group (microdrilling, hyaluronic acid, and apheretic product). Outcome measurements included weight-bearing on the operated limb, macroscopic scoring of the joint, histology, and immunohistochemistry. In addition, magnetic resonance imaging was used to attempt to identify SPION-labeled cells from the apheretic product in the operated limbs. The results showed a significant increase in healing as measured by the modified O'Driscoll sore in the treated group. No evidence of homing of SPION-labeled cells to the defect was found and no correlation was found between the response to G-CSF administration or concentration of CD34

Indexed as

Granulocyte Colony-Stimulating FactorPeripheral Blood Stem Cell TransplantationAnimalsArthroplasty, SubchondralBlood Component RemovalFemaleSheepTransplantation, AutologousGranulocyte Colony-Stimulating Factorapheresiscartilage healingchondral defectovine

Identifiers

PMID33146412
PMCPMC7612025

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.