ArticleCephalalgia : an international journal of headache2020
Isolated intracranial hypertension associated with COVID-19.
Article in Cephalalgia : an international journal of headache, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Headaches and facial pain attributed to SARS-CoV-2 infection and vaccination: a systematic review.European journal of neurology · 2024Pooled it
- Cerebrospinal fluid analysis in patients with COVID-19-associated central nervous system manifestations: a systematic review.Arquivos de neuro-psiquiatria · 2022Pooled it
- Cerebrospinal fluid from COVID-19 patients with olfactory/gustatory dysfunction: A review.Clinical neurology and neurosurgery · 2021Pooled it
- Cerebrospinal fluid in COVID-19: A systematic review of the literature.Journal of the neurological sciences · 2021Pooled it
- Central nervous system and systemic inflammatory networks associated with acute neurological outcomes in COVID-19.Scientific reports · 2025Article
- Idiopathic intracranial hypertension associated with SARS-CoV-2 infection in an adult male patient: a case report and review of the literature.Journal of medical case reports · 2024Review
- Intracranial hypertension after rosacea treatment with isotretinoin.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Headache in COVID-19 and Long COVID: to Know Facts for Clinical Practice.Current neurology and neuroscience reports · 2023Review
- COVID-19 in the nervous system: physiopathology and neurological manifestations.Arquivos de neuro-psiquiatria · 2023Review
- Neuro-Ophthalmic Complications of COVID-19 Infection and Vaccination.Advances in ophthalmology and optometry · 2023Review
- Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri.Brain sciences · 2023Article
- SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System.Neuroscience insights · 2023Article
- Optic nerve sheath diameter is associated with outcome in severe Covid-19.Scientific reports · 2022Article
- De Novo Presentation of Idiopathic Intracranial Hypertension (IIH) Associated With COVID-19 Infection.The Neurohospitalist · 2022Article
- Idiopathic intracranial hypertension as a neurological manifestation of COVID-19: A case report.Journal francais d'ophtalmologie · 2022Article
- COVID-19 and Ventricular Shunt Revisions.Cureus · 2022Article
- Headache associated with COVID-19: Epidemiology, characteristics, pathophysiology, and management.Headache · 2022Review
- The diagnostic dilemma of idiopathic intracranial hypertension in a child with acute lymphoblastic leukemia: COVID-19 or cytosine arabinoside?BMC neurology · 2022Article
- Normal pressure hydrocephalus associated with COVID-19 infection: a case report.BMC infectious diseases · 2022Article
- Understanding the role of nACE2 in neurogenic hypertension among COVID-19 patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeadache is a frequent complaint in COVID-19 patients. However, no detailed information on headache characteristics is provided in these reports. Our objective is to describe the characteristics of headache and the cerebrospinal fluid (CSF) profile in COVID-19 patients, highlighting the cases of isolated intracranial hypertension.
methodsIn this cross-sectional study, we selected COVID-19 patients who underwent lumbar puncture due to neurological complaints from April to May 2020. We reviewed clinical, imaging, and laboratory data of patients with refractory headache in the absence of other encephalitic or meningitic features. CSF opening pressures higher than 250 mmH
resultsFifty-six COVID-19 patients underwent lumbar puncture for different neurological conditions. A new, persistent headache that prompted a CSF analysis was diagnosed in 13 (23.2%). The pain was throbbing, holocranial or bilateral in the majority of patients. All patients had normal CSF analysis and RT-qPCR for SARS-CoV-2 was negative in all samples. Opening pressure >200 mmH
conclusionsIn a significant proportion of COVID-19 patients, headache was associated to intracranial hypertension in the absence of meningitic or encephalitic features. Coagulopathy associated with COVID-19 could be an explanation, but further studies including post-mortem analysis of areas of production and CSF absorption (choroid plexuses and arachnoid granulations) are necessary to clarify this issue.
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