ArticleCephalalgia : an international journal of headache2020
Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.
Article in Cephalalgia : an international journal of headache, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05704335 (INFLUENCEF STUDY), which is not on this map. Cited by 122 papers, 8 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INFLUENCEF STUDY: Epidemiology, Risk Factors and Clinical Phenotype of Headache Associated With Influenza Infection
Who cites it
122 citing papers in PubMed, 8 syntheses or guidelines pooled it, 229 citations in OpenAlex.
- Migraine-like headaches: a systematic review of secondary etiologies, clinical features and therapeutic patterns (1977-2024).The journal of headache and pain · 2025Pooled it
- Efficacy and safety of simple analgesics for acute treatment of episodic tension-type headache in adults: a network meta-analysis.Annals of medicine · 2024Pooled it
- Headaches and facial pain attributed to SARS-CoV-2 infection and vaccination: a systematic review.European journal of neurology · 2024Pooled it
- Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study.Journal of intensive care medicine · 2023Pooled it
- Late neurological consequences of SARS-CoV-2 infection: New challenges for the neurologist.Frontiers in neuroscience · 2023Pooled it
- Pooled it
- What can the neurological manifestations of COVID-19 tell us: a meta-analysis.Journal of translational medicine · 2021Pooled it
- Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data.Frontiers in medicine · 2021Pooled it
- Clinical Manifestations Associated with Pain in Nursing Students in Emerging Adulthood with Long COVID.Nursing reports (Pavia, Italy) · 2026Article
- Understanding the long-term neurological effects of SARS-CoV-2 infection.Nature reviews. Neurology · 2026Review
- Intranasal SARS-CoV-2 infection changes the transcriptome of the mouse trigeminal ganglion and brainstem: potential mechanisms underlying headache and trigeminal pain presentation in COVID-19.Journal of neuroinflammation · 2026Article
- New-Onset Headache After SARS-CoV-2 Infection and Vaccination: Results From Three Population-Based Cohorts in Norway.European journal of neurology · 2025Article
- COVID-19 Vaccination Modifies COVID-19-Related Headache Phenotype: Evidence from Case-Control Study on 309 Participants.Biomedicines · 2025Article
- Patterns of Past COVID-19 and EBV Infection in Primary Headache Disorders: A Population Study.Brain and behavior · 2025Article
- Long-Term Persistent Headache After SARS-CoV-2 Infection: A Follow-Up Population-Based Study.European journal of neurology · 2025Article
- Review
- Significance of Neurological Manifestations and Their Association With Clinical Outcomes in Hospitalized COVID-19 Patients in Bandar Abbas, Iran: A Cross-Sectional Study.Health science reports · 2025Article
- Brain Structural Abnormalities in Patients with Post-COVID-19 Headache.Neurology international · 2025Article
- Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.Medical hypotheses · 2025Article
- Health Resort Treatment Mitigates Neuropsychiatric Symptoms in Long COVID Patients: A Retrospective Study.Healthcare (Basel, Switzerland) · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo define headache characteristics and evolution in relation to COVID-19 and its inflammatory response.
methodsThis is a prospective study, comparing clinical data and inflammatory biomarkers of COVID-19 patients with and without headache, recruited at the Emergency Room. We compared baseline with 6-week follow-up to evaluate disease evolution.
resultsOf 130 patients, 74.6% (97/130) had headache. In all, 24.7% (24/97) of patients had severe pain with migraine-like features. Patients with headache had more anosmia/ageusia (54.6% vs. 18.2%;
conclusionsHeadache associated with COVID-19 is a frequent symptom, predictive of a shorter COVID-19 clinical course. Disabling headache can persist after COVID-19 resolution. Pathophysiologically, its migraine-like features may reflect an activation of the trigeminovascular system by inflammation or direct involvement of SARS-CoV-2, a hypothesis supported by concomitant anosmia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.