Evidence map›Paper›PMID 33145984›Full record

Trial reportPharmacology research & perspectives2020

The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial.

Noha O Mansour, Amal Ahmed Mohamed, Maha Hussein, Eman Eldemiry, Aliaa Daifalla, Soha Hassanin, Nourelhuda Nassar, Doaa Ghaith, Eman Mohamed Salah

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pharmacology research & perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Review
  8. Review
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  10. Review
  11. Review
  12. Review
  13. Review
  14. Vitamin D in the Prevention and Treatment of Inflammatory Skin Diseases.International journal of molecular sciences · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Vitamin D and allergic diseases.Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 1 country.

Noha O MansourPharmacy Practice Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.ORCID 0000-0002-4448-994X
Amal Ahmed MohamedBiochemistry Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Maha HusseinDepartment of Dermatology and Andrology, National Research Centre, Cairo, Egypt.
Eman EldemiryFaculty of Pharmacy, Fellow of Clinical Pharmacology, Cairo University Hospitals, Giza, Egypt.
Aliaa DaifallaDepartment of Dermatology, Venerology, and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.
Soha HassaninBiochemistry Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.ORCID 0000-0001-8568-1033
Nourelhuda NassarClinical Pathology Department, Elsahel Teaching Hospital, Cairo, Egypt.
Doaa GhaithClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Eman Mohamed SalahDepartment of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine, Helwan University, Cairo, Egypt.
Benha University · EGCairo University · EGCairo University hospitals · EGHelwan University · EGMansoura University · EGModern University for Information and Technology · EGNational Research Centre · EGNational Water Research Center · EGResearch Institute of Ophthalmology · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D supplementation with standard treatment yielded positive clinical outcomes in mild and moderate atopic dermatitis; however, the potential benefit of vitamin D in severe cases remains unclear. This study aimed to evaluate the impact of vitamin D supplementation on response to standard treatment in pediatrics with severe atopic dermatitis. The patients were randomized to receive either vitamin D 3 1600 IU/day or placebo, plus baseline therapy of topical 1% hydrocortisone cream twice daily for 12 weeks. The primary endpoints were the change in mean Eczema Area and Severity Index (EASI) score at the end of the study and the mean percent change in EASI score from baseline to week 12. Eighty-six subjects completed the study. The treated group achieved a significant higher level of 25 hydroxy vitamin D (P < .001) compared to control group at week 12. The mean EASI score was significantly lower in the treatment group compared to placebo group (P = .035). The percent change in EASI score from baseline differed significantly between the supplementation (56.44 ± 29.33) and placebo (42.09 ± 19.22) groups after intervention (P = .039). Vitamin D supplementation could be an effective adjuvant treatment that improves the clinical outcomes in severe atopic dermatitis.

Indexed as

Dietary SupplementsSeverity of Illness IndexAdolescentChemotherapy, AdjuvantChildChild, PreschoolDermatitis, AtopicDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleTreatment OutcomeVitamin DVitamin Datopic dermatitisEczemaseverevitamin D

Identifiers

PMID33145984
PMCPMC7609811
OpenAlexW3097917733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.