ReviewJournal of neuroendocrinology2021
Birth signalling hormones and the developmental consequences of caesarean delivery.
Review in Journal of neuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Mechanistic Pathways Underlying Breastfeeding Challenges Following Cesarean Delivery: A Systematic Review.Nutrients · 2026Pooled it
- Pooled it
- Parental microbiome programming of early-life neurodevelopment: multi-niche contributions through the microbiome-gut-brain axis.Gut microbes · 2026Review
- Impact of Cesarean Delivery on Reward Behavior and Tyrosine Hydroxylase in the Nucleus Accumbens of Adult Prairie Vole Offspring.Developmental psychobiology · 2026Article
- Evolved birth physiology meets modern birth practice: Sustained effects of planned cesarean delivery on child hair cortisol in Brazil.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Perinatal insult dimensions and developmental trajectories of psychotic-like experiences.Schizophrenia (Heidelberg, Germany) · 2025Article
- Beyond Pain Management: Skin-to-Skin Contact as a Humanization Strategy in Cesarean Delivery: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- Understanding the interplay of Caesarean delivery and genetic influences on intelligence and anxiety traits in offspring findings from genome-wide association studies.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- A multi-level meta-analysis of the relationship between decision-making during birth and postpartum mental health.Health psychology and behavioral medicine · 2025Review
- Delivery by cesarean section leads to heavier adult bodyweight in prairie voles (Microtus ochrogaster).Hormones and behavior · 2024Article
- New policies on skin-to-skin contact warrant an oxytocin-based perspective on perinatal health care.Frontiers in psychology · 2024Article
- Access, Interest, and Barriers to Incorporation of Birth Doula Care in the United States.The Journal of perinatal education · 2023Article
- Close encounters with oxytocin.Comprehensive psychoneuroendocrinology · 2023Review
- Neuroanatomical and functional consequences of oxytocin treatment at birth in prairie voles.Psychoneuroendocrinology · 2023Article
- Lasting consequences on physiology and social behavior following cesarean delivery in prairie voles.Hormones and behavior · 2023Article
- Sex, love and oxytocin: Two metaphors and a molecule.Neuroscience and biobehavioral reviews · 2022Review
- Oxytocin and oxygen: the evolution of a solution to the 'stress of life'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Oxytocin and love: Myths, metaphors and mysteries.Comprehensive psychoneuroendocrinology · 2022Review
- Article
- What is an appropriate caesarean delivery rate for China: a multicentre survey.BJOG : an international journal of obstetrics and gynaecology · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Rates of delivery by caesarean section (CS) are increasing around the globe and, although several epidemiological associations have already been observed between CS and health outcomes in later life, more are sure to be discovered as this practice continues to gain popularity. The components of vaginal delivery that protect offspring from the negative consequences of CS delivery in later life are currently unknown, although much attention to date has focused on differences in microbial colonisation. Here, we present the case that differing hormonal experiences at birth may also contribute to the neurodevelopmental consequences of CS delivery. Levels of each of the 'birth signalling hormones' (oxytocin, arginine vasopressin, epinephrine, norepinephrine and the glucocorticoids) are lower following CS compared to vaginal delivery, and there is substantial evidence for each that manipulations in early life results in long-term neurodevelopmental consequences. We draw from the research traditions of neuroendocrinology and developmental psychobiology to suggest that the perinatal period is a sensitive period, during which hormones achieve organisational effects. Furthermore, there is much to be learned from research on developmental programming by early-life stress that may inform research on CS, as a result of shared neuroendocrine mechanisms at work. We compare and contrast the effects of early-life stress with those of CS delivery and propose new avenues of research based on the links between the two bodies of literature. The research conducted to date suggests that the differences in hormone signalling seen in CS neonates may produce long-term neurodevelopmental consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.