Evidence map›Paper›PMID 33145730›Full record

ArticleEnvironmental science and pollution research international2021

Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease.

Gaurav Bhatia, Jatinder Singh, Bimla Nehru

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Bacopa Protects against Neurotoxicity Induced by MPPMolecules (Basel, Switzerland) · 2022
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gaurav BhatiaDepartment of Biophysics, Basic Medical Sciences Block, Panjab University, Chandigarh, 160014, India.
Jatinder SinghDepartment of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Bimla NehruDepartment of Biophysics, Basic Medical Sciences Block, Panjab University, Chandigarh, 160014, India. bnehru@pu.ac.in.ORCID http://orcid.org/0000-0001-5427-7441
Panjab University · INGuru Nanak Dev University · IN

Funding

Science and Engineering Research Board PDF/2016/002737
6 · The paper itself

Abstract

Pathogenesis of Parkinson's disease (PD) specifically involves the degeneration of dopaminergic neurons in the substantia nigra region, which mainly begun with the overwhelmed oxidative stress and neuroinflammation. Considering the antioxidant and other pharmacological properties, Eclipta alba needs to be exploited for its possible neuroprotective efficacy against PD and other neurological disorders. Therefore, the current study was conducted to exemplify the remedial effects of hydro-alcoholic extract of E. alba (EA-MEx) against MPP

Indexed as

EcliptaNeuroprotective AgentsParkinson Disease1-Methyl-4-phenylpyridiniumAnimalsApoptosisCell Line, TumorMalePlant ExtractsRatsRats, Wistar1-Methyl-4-phenylpyridiniumNeuroprotective AgentsPlant ExtractsEclipta albaIn vivo PD modelMortalinMPP+SH-SY5Y cellsTyrosine hydroxylaseα-Synuclein

Identifiers

PMID33145730
OpenAlexW3094689179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.