Evidence map›Paper›PMID 33145678›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2021

Cadmium exposure negatively affects the microarchitecture of trabecular bone and decreases the density of a subset of sympathetic nerve fibers innervating the developing rat femur.

Mayra A Graniel-Amador, Héctor F Torres-Rodríguez, Juan M Jiménez-Andrade, Joel Hernández-Rodríguez, Marcela Arteaga-Silva, Sergio Montes

Abstract read
PubMed Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  3. Mo and Sn exposure associated with the increased of bone mineral density.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mayra A Graniel-AmadorUnidad Académica Multidisciplinaria Reynosa Aztlán, Universidad Autónoma de Tamaulipas, 88740, Reynosa, Tamaulipas, Mexico.
Héctor F Torres-RodríguezUnidad Académica Multidisciplinaria Reynosa Aztlán, Universidad Autónoma de Tamaulipas, 88740, Reynosa, Tamaulipas, Mexico.
Juan M Jiménez-AndradeUnidad Académica Multidisciplinaria Reynosa Aztlán, Universidad Autónoma de Tamaulipas, 88740, Reynosa, Tamaulipas, Mexico.
Joel Hernández-RodríguezDepartamento de Biología de la Reproducción, DCBS, Universidad Autónoma Metropolitana- Iztapalapa, Av. San Rafael Atlixco 186, Leyes de Reforma 1ra Sección, 09340, CDMX, Mexico.
Marcela Arteaga-SilvaDepartamento de Biología de la Reproducción, DCBS, Universidad Autónoma Metropolitana- Iztapalapa, Av. San Rafael Atlixco 186, Leyes de Reforma 1ra Sección, 09340, CDMX, Mexico.
Sergio MontesDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suárez", Insurgentes sur 3877, 14269, Tlalpan, CDMX, Mexico. smontes@innn.edu.mx.ORCID 0000-0002-0138-0784
Autonomous University of Tamaulipas · MXUniversidad Autónoma Metropolitana · MXInstituto Nacional de Neurología y Neurocirugía · MX

Funding

CONACyT (Mx) 622536/570248Universidad Autónoma Metropolitana Unidad Iztapalapa CD.CBS.535.2018
6 · The paper itself

Abstract

Cadmium (Cd) is toxic to the skeletal system resulting in bone loss and pain. We aimed at determining the effect of chronic Cd exposure on bone density and microarchitecture along with changes in the density of a subset of sensory and sympathetic nerve fibers innervating the developing rat femur. Newborn male Wistar rats were injected daily for 49 days with CdCl

Indexed as

AnimalsBone DensityCadmiumCancellous BoneFemaleFemurInjections, IntraperitonealNerve FibersPregnancyRatsRats, WistarCadmiumBone lossCadmiumDeveloping boneInnervationToxicity

Identifiers

PMID33145678
OpenAlexW3095036278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.