Evidence map›Paper›PMID 33145461›Full record

ArticleJACC. Basic to translational science2020

Human Dorsal Root Ganglion Stimulation Reduces Sympathetic Outflow and Long-Term Blood Pressure.

Yrsa B Sverrisdottir, Sean C Martin, George Hadjipavlou, Alexander R Kent, David J Paterson, James J FitzGerald, Alexander L Green

Abstract read
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In one paragraph

Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yrsa B SverrisdottirNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Sean C MartinNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
George HadjipavlouNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Alexander R KentNeuromodulation Applied Research, Abbott, Sunnyvale, California.
David J PatersonDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
James J FitzGeraldNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Alexander L GreenNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study hypothesized that dorsal root ganglion (DRG) stimulation would reduce sympathetic nerve activity and would alter hemodynamic variables. This study directly recorded muscle sympathetic nerve activity during ON and OFF stimulation of the DRG while measuring hemodynamic parameters. DRG stimulation significantly reduced the firing frequency of sympathetic nerves, as well as significantly reducing blood pressure, with greater reductions evident when stimulation was left-sided. Left-sided DRG stimulation lowers sympathetic nerve activity, leading to long-term phenotypic changes. This raises the potential of DRG stimulation being used to treat de novo autonomic disorders such as hypertension or heart failure.

Indexed as

BF, burst frequencyBI, burst incidenceblood pressureBP, blood pressureDBP, diastolic blood pressureDRG, dorsal root ganglionDRGS, dorsal root ganglion stimulationDRG stimulationHR, heart ratehypertensionMAP, mean arterial pressureMME, morphine milligram equivalentMRBA%, median relative burst amplitudeMSNA, muscle sympathetic nerve activityneuromodulationSBP, systolic blood pressureSCS, spinal cord stimulationsympathetic nerve activityVAS, visual analogue score of pain

Identifiers

PMID33145461
PMCPMC7591825

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.