Evidence map›Paper›PMID 33145362›Full record

ArticleBioMed research international2020

Antioxidant Function and Metabolomics Study in Mice after Dietary Supplementation with Methionine.

Manrong Yu, Hui Chen, Pan Liu, Mei Yang, Leqin Zou, Dingfu Xiao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Manrong YuCollege of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China.
Hui ChenCollege of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China.
Pan LiuCollege of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China.
Mei YangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China.
Leqin ZouCollege of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China.
Dingfu XiaoCollege of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China.ORCID https://orcid.org/0000-0002-7071-3888
Hunan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antioxidant function and metabolic profiles in mice after dietary supplementation with methionine were investigated. The results showed that methionine supplementation enhanced liver GSH-Px activity and upregulated Gpx1 expression in the liver and SOD1 and Gpx4 expressions in the jejunum. Nrf2/Keap1 is involved in oxidative stress, and the western blotting data exhibited that dietary methionine markedly increased Keap1 abundance, while failed to influence the Nrf2 signal. Metabolomics investigation showed that methionine administration increased 2-hydroxypyridine, salicin, and asparagine and reduced D-Talose, maltose, aminoisobutyric acid, and inosine 5'-monophosphate in the liver, which are widely reported to involve in oxidative stress, lipid metabolism, and nucleotides generation. In conclusion, our study provides insights into antioxidant function and liver metabolic profiles in response to dietary supplementation with methionine.

Indexed as

Dietary SupplementsAminoisobutyric AcidsAnimalsAntioxidantsAsparagineBenzyl AlcoholsDietFemaleGene Expression RegulationGlucosidesGlutathione PeroxidaseGlutathione Peroxidase GPX1Inosine MonophosphateJejunumKelch-Like ECH-Associated Protein 1Lactones2-hydroxypyridineAminoisobutyric AcidsAntioxidantsAsparagineBenzyl AlcoholsGlucosidesGlutathione Peroxidaseglutathione peroxidase 4, mouseGlutathione Peroxidase GPX1Gpx1 protein, mouseInosine MonophosphateKeap1 protein, mouseKelch-Like ECH-Associated Protein 1LactonesL-talo-gamma-lactoneMaltoseMethionineNfe2l2 protein, mouseNF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidasePyridonessalicinSod1 protein, mouseSuperoxide Dismutase-1

Identifiers

PMID33145362
PMCPMC7596454
OpenAlexW3094386417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.