Evidence map›Paper›PMID 33145357›Full record

ArticleBioMed research international2020

Preparation and Nanoencapsulation of Lectin from

Unzila Yasin, Muhammad Bilal, Hamid Bashir, Muhammad Imran Amirzada, Aleena Sumrin, Muhammad Hassham Hassan Bin Asad

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Applications of mannose-binding lectins and mannan glycoconjugates in nanomedicine.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Unzila YasinCentre for Applied Molecular Biology, University of the Punjab, 87-West Canal, Bank Road Lahore-53700, Pakistan.
Muhammad BilalCentre for Applied Molecular Biology, University of the Punjab, 87-West Canal, Bank Road Lahore-53700, Pakistan.
Hamid BashirCentre for Applied Molecular Biology, University of the Punjab, 87-West Canal, Bank Road Lahore-53700, Pakistan.ORCID https://orcid.org/0000-0002-1172-5117
Muhammad Imran AmirzadaDepartment of Pharmacy, COMSATS University, Islamabad, Abbottabad Campus, 22060, Pakistan.
Aleena SumrinCentre for Applied Molecular Biology, University of the Punjab, 87-West Canal, Bank Road Lahore-53700, Pakistan.
Muhammad Hassham Hassan Bin AsadDepartment of Pharmacy, COMSATS University, Islamabad, Abbottabad Campus, 22060, Pakistan.ORCID https://orcid.org/0000-0002-2739-9416
University of the Punjab · PKCOMSATS University Islamabad · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lectins are the oligomeric sugar-specific glycoprotein of nonimmune origin, are involved in the multiple biological recognition process, and have the capacity to perform a wide variety of physiological functions including antifungal, antiviral, antitumor, and cell agglutination. The main objective of the current study was to prepare lectin protein-loaded chitosan-TPP nanoparticles via ionic gelation methods with different CS/TPP ratios and to investigate anticancer potential against HepG2 cells. The best ratio showed the mean particle size (298.10 ± 1.9 nm, 21.05 ± 0.95 mv) with optimal encapsulation efficiencies of 52.435 ± 0.09%. The cytotoxicity was evaluated against HepG2 cells, and IC

Indexed as

alpha-FetoproteinsAntineoplastic Agents, PhytogenicApoptosisbcl-2-Associated X ProteinCaspase 3ChitosanDrug CarriersDrug CompoundingGelsGene Expression Regulation, NeoplasticHep G2 CellsHumansInhibitory Concentration 50LectinsLepidium sativumNanoparticlesAFP protein, humanalpha-FetoproteinsAntineoplastic Agents, PhytogenicBAX protein, humanbcl-2-Associated X ProteinBCL2 protein, humanCASP3 protein, humanCaspase 3Chitosanchitosan-tripolyphosphateDrug CarriersGelsLectinsProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53

Identifiers

PMID33145357
PMCPMC7599413
OpenAlexW3093854213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.