Evidence map›Paper›PMID 33145344›Full record

ArticleBioMed research international2020

Mesenteric Lymph Duct Drainage Attenuates Lung Inflammatory Injury and Inhibits Endothelial Cell Apoptosis in Septic Rats.

Yongjun Liu, Chuanxi Chen, Qing Sun, Huadong Sun, Ning Liu, Qier Liu, Jie Ma, Pingping Wang, Chunlin Hu, Jianfeng Wu and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Yongjun LiuDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0002-6402-3389
Chuanxi ChenDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0001-9351-4315
Qing SunDepartment of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China.ORCID https://orcid.org/0000-0003-3027-2253
Huadong SunDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0002-5688-4234
Ning LiuDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0001-8173-3393
Qier LiuDepartment of Molecular and Cell Biology, College of Liberal Arts and Sciences, University of Connecticut, Storrs, Connecticut 06269, USA.ORCID https://orcid.org/0000-0003-1060-2905
Jie MaDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0003-4147-933X
Pingping WangDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0003-4165-5292
Chunlin HuDepartment of Emergency, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0002-9510-0957
Jianfeng WuDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0001-9098-2500
Bin OuyangDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0001-8735-4335
Juan ChenDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0001-8246-8763
Minying ChenDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0001-7646-1311
Xiangdong GuanDepartment of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0001-7880-0719
Sun Yat-sen University · CNUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study was to investigate the effect of mesenteric lymph duct drainage on lung inflammatory response, histological alteration, and endothelial cell apoptosis in septic rats. Animals were randomly assigned into four groups: control, sham surgery, sepsis, and sepsis plus mesenteric lymph drainage. We used the colon ascendens stent peritonitis (CASP) procedure to induce the septic model in rats, and mesenteric lymph drainage was performed with a polyethylene (PE) catheter inserted into mesenteric lymphatic. The animals were sacrificed at the end of CASP in 6 h. The mRNA expression levels of inflammatory mediators were measured by qPCR, and the histologic damage were evaluated by the pathological score method. It was found that mesenteric lymph drainage significantly reduced the expression of TNF-

Indexed as

AnimalsApoptosisBiological FactorsDisease Models, AnimalDrainageEndothelial CellsGene Expression RegulationInterleukin-1betaInterleukin-6LymphLymphatic VesselsMaleMesenteryPeritonitisPeroxidasePneumoniaBiological FactorsIL1B protein, ratIl6 protein, ratInterleukin-1betaInterleukin-6PeroxidaseTumor Necrosis Factor-alpha

Identifiers

PMID33145344
PMCPMC7596461
OpenAlexW3094114275

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.