Evidence map›Paper›PMID 33145274›Full record

ArticleAnnals of translational medicine2020

Repeated radioembolization in advanced liver cancer.

Max Masthoff, Philipp Schindler, Fabian Harders, Walter Heindel, Christian Wilms, Hartmut H Schmidt, Andreas Pascher, Lars Stegger, Kambiz Rahbar, Moritz Wildgruber and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Max MasthoffInstitute of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
Philipp SchindlerInstitute of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
Fabian HardersInstitute of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
Walter HeindelInstitute of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
Christian WilmsDepartment of Gastroenterology and Hepatology, University Hospital Muenster, Muenster, Germany.
Hartmut H SchmidtDepartment of Gastroenterology and Hepatology, University Hospital Muenster, Muenster, Germany.
Andreas PascherDepartment for General, Visceral and Transplantation Surgery, University Hospital Muenster, Muenster, Germany.
Lars SteggerDepartment of Nuclear Medicine, University Hospital Muenster, Muenster, Germany.
Kambiz RahbarDepartment of Nuclear Medicine, University Hospital Muenster, Muenster, Germany.
Moritz WildgruberInstitute of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
Michael KöhlerInstitute of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
University Hospital Münster · DELMU Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate safety and clinical outcome of repeated transarterial

methodsBetween 2009 and 2018, n=288 patients underwent TARE for treatment of malignant liver disease in a tertiary care hospital. This retrospective single center study analyzed the safety and outcome of patients (n=11/288) undergoing repeated resin microsphere TARE. Included patients suffered from hepatocellular carcinoma (n=3), colorectal cancer (n=2), breast cancer (n=2), intrahepatic cholangiocarcinoma (n=3), and neuroendocrine carcinoma (n=1). All patients had shown either partial response (n=9) or stable disease (n=2) after first TARE. Lab parameters, response assessed by the Response Evaluation Criteria in Solid Tumors (mRECIST/RECIST) at 3 months and overall survival was analyzed. Additionally, patients with repeated TARE were compared to a matched control group (n=56) with single TARE therapy. Kaplan Meier analysis was performed to analyze survival.

resultsPatients after repeated TARE showed similar increase in lab parameters as compared to their first TARE. No case of radioembolization induced liver disease was observed. While n=5/11 patients showed a partial response and n=4/11 patients a stable disease after repeated TARE, only n=2/11 patients suffered from progressive disease. Median overall survival was 20.9±11.9 months for the repeated TARE group while it was 5.9±16.2 months for the control group.

conclusionsRepeated

Indexed as

90Y yttriumliver cancerRepeated radioembolization

Identifiers

PMID33145274
PMCPMC7575953
OpenAlexW3082769929

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.