Evidence map›Paper›PMID 33145270›Full record

ArticleAnnals of translational medicine2020

Differential expression of genes related to calcineurin and mTOR signaling and regulatory miRNAs in peripheral blood from kidney recipients under tacrolimus-based therapy.

Vivian Bonezi, Fabiana Dalla Vecchia Genvigir, Patrícia de Cássia Salgado, Claudia Rosso Felipe, Helio Tedesco-Silva, José Osmar Medina-Pestana, Alvaro Cerda, Sonia Quateli Doi, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Vivian BoneziDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Fabiana Dalla Vecchia GenvigirDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Patrícia de Cássia SalgadoDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Claudia Rosso FelipeNephrology Division, Hospital do Rim, Federal University of Sao Paulo, Sao Paulo, Brazil.
Helio Tedesco-SilvaNephrology Division, Hospital do Rim, Federal University of Sao Paulo, Sao Paulo, Brazil.
José Osmar Medina-PestanaNephrology Division, Hospital do Rim, Federal University of Sao Paulo, Sao Paulo, Brazil.
Alvaro CerdaDepartment of Basic Sciences, Center of Excellence in Translational Medicine, BIOREN, Universidad de La Frontera, Temuco, Chile.
Sonia Quateli DoiSchool of Medicine, Uniformed Services University, Bethesda, MD, USA.
Mario Hiroyuki HirataDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Rosario Dominguez Crespo HirataDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRHospital do Rim e Hipertensão · BRUniformed Services University of the Health Sciences · USUniversidad de La Frontera · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic and epigenetics factors have been implicated in drug response, graft function and rejection in solid organ transplantation. Differential expression of genes involved in calcineurin and mTOR signaling pathway and regulatory miRNAs was analyzed in the peripheral blood of kidney recipient cohort (n=36) under tacrolimus-based therapy.

methods

results

conclusionsThe expression of

Indexed as

Circulating miRNAsgene expressionkidney transplantpharmacogenomics

Identifiers

PMID33145270
PMCPMC7575939
OpenAlexW3084965380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.