Evidence map›Paper›PMID 33145169›Full record

ArticleMolecular genetics and metabolism reports2020

Copy number variant analysis and expression profiling of the olfactory receptor-rich 11q11 region in obesity predisposition.

Sara Diels, Sander Huybreghts, Kim Van Hoorenbeeck, Guy Massa, An Verrijken, Stijn L Verhulst, Luc F Van Gaal, Wim Van Hul

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Article in Molecular genetics and metabolism reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara DielsDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium.
Sander HuybreghtsDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium.
Kim Van HoorenbeeckDepartment of Pediatrics, Antwerp University Hospital, Antwerp, Belgium.
Guy MassaDepartment of Pediatrics, Jessa Hospital, Hasselt, Belgium.
An VerrijkenDepartment of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Antwerp, Belgium.
Stijn L VerhulstDepartment of Pediatrics, Antwerp University Hospital, Antwerp, Belgium.
Luc F Van GaalDepartment of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Antwerp, Belgium.
Wim Van HulDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide copy number surveys associated chromosome 11q11 with obesity. As this is an olfactory receptor-rich region, we hypothesize that genetic variation in olfactory receptor genes might be implicated in the pathogenesis of obesity. Multiplex Amplicon Quantification analysis was applied to screen for copy number variants at chromosome 11q11 in 627 patients with obesity and 330 healthy-weight individuals. A ± 80 kb deletion with an internally 1.3 kb retained segment was identified, covering the three olfactory receptor genes

Indexed as

Chromosome 11q11Copy number variantExpression profilingObesityOlfactory receptor

Identifiers

PMID33145169
PMCPMC7596328

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.