Evidence map›Paper›PMID 33145153›Full record

ReviewJournal of bone oncology2020

Potential diagnostic value of circulating miRNA for multiple myeloma: A meta-analysis.

Shuai-Shuai Gao, Yan-Jun Wang, Guo-Xun Zhang, Wen-Ting Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Journal of bone oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shuai-Shuai GaoDepartment of Traumatology and Orthopedic Surgery, Xi'an Daxing Hospital, Shaanxi, China.
Yan-Jun WangDepartment of Traumatology and Orthopedic Surgery, Xi'an Daxing Hospital, Shaanxi, China.
Guo-Xun ZhangInternational Doctoral School, University of Seville, Spain.
Wen-Ting ZhangInternational Doctoral School, University of Seville, Spain.
Universidad de Sevilla · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple myeloma (MM) is the second incurable hematological malignancy. In recent years, due to the rise of microRNA (miRNA), many scholars have participated in the study of its value in the diagnosis of MM, and have obtained good but inconsistent results. Therefore, in order to determine the role of miRNA in the early diagnosis of MM, we performed this

methodsWe searched for related studies including PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang Database as of July 20, 2020 to conduct this

resultsWe finally collected 32 studies from 15 articles that included a total of 2053 MM patients and 1118 healthy controls in this

conclusionsCirculating miRNA could be a potential non-invasive biomarker for early diagnosis of MM. However, multi-center, more rigorous, and larger-scale studies are needed to verify our conclusions.

Indexed as

AUC, Area under the curveCI, confidence intervalDiagnosisDOR, Diagnostic odds ratioMeta-analysisMGUS, Monoclonal gammopathy of undetermined significancemicroRNA, miRNAMicroRNAsMM, Multiple myelomaMultiple myelomaNLR, Negative likelihood ratioPCL, Plasma cell leukemiaPLR, Positive likelihood ratioQUADAS-2, Quality Assessment of Diagnostic Accuracy Study 2SE, SensitivitySP, Specificity

Identifiers

PMID33145153
PMCPMC7596263
OpenAlexW3093617331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.