ArticleJournal of thoracic disease2020
Active tuberculosis risk associated with malignancies: an 18-year retrospective cohort study in Korea.
Article in Journal of thoracic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Burden of tuberculosis among patients with cancer: a comprehensive systematic review and meta-analysis of global data.JNCI cancer spectrum · 2025Pooled it
- Comorbidity profiles and their impact on treatment outcomes in elderly patients with pulmonary tuberculosis: a single-center retrospective cohort study.BMC infectious diseases · 2026Article
- A Case of Pancreatic Cancer Complicated by Active Pulmonary Tuberculosis Successfully Managed through a Multidisciplinary Treatment Strategy.Surgical case reports · 2026Article
- Active Tuberculosis Risk Associated with Malignancies: A 4-Year Retrospective Study in a Tertiary Care Hospital.South Asian journal of cancer · 2025Article
- Coexistent Pulmonary Tuberculosis and Lung Cancer: An Analysis of Incidence Trends, Financial Burdens and Influencing Factors.Cancer innovation · 2025Article
- Clinical and imaging features of co-existent pulmonary tuberculosis and lung cancer: a population-based matching study in China.BMC cancer · 2025Article
- Establishment and validation of a convenient and efficient screening tool for active pulmonary tuberculosis in lung cancer patients based on common parameters.Therapeutic advances in medical oncology · 2025Article
- Host Risk Factors for Tuberculosis.Infectious disorders drug targets · 2025Review
- Incidence and risk factors of tuberculosis in patients following gastrectomy or endoscopic submucosal dissection: a cohort analysis of country-level data.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- A scoping review on the risk of tuberculosis in specific population groups: can we expand the World Health Organization recommendations?European respiratory review : an official journal of the European Respiratory Society · 2023Article
- COVID-19 pneumonia and the subsequent risk of getting active pulmonary tuberculosis: a population-based dynamic cohort study using national insurance claims databases.EClinicalMedicine · 2023Article
- Incidence and Risk of Lung Cancer in Tuberculosis Patients, and Vice Versa: A Literature Review of the Last Decade.BioMed research international · 2022Review
- Are there common threads in the susceptibility to cancer and tuberculosis?Journal of thoracic disease · 2020Article
- Immune Checkpoint Inhibitors in Special Populations.Technology in cancer research & treatmentReview
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActive tuberculosis (TB) develops in approximately 10% of people with a latent tuberculosis infection (LTBI). TB guidelines recommend that LTBI screening and treatments target high-risk patients. Malignancies are not universally considered a high-risk factor for active TB. This study aimed to determine the degrees to which active TB risk was associated with various cancers in a Korean population.
methodsThis study involved patients aged ≥20 years who were diagnosed with cancer at Ulsan University Hospital (UUH) from January 2000 to December 2014 and individuals who visited UUH for health screening and were age- and sex-matched randomly with cases in a 1:2 ratio. Using retrospective cohort study, the development of bacteriologically confirmed TB (BCTB) within 3 years after enrollment was investigated. The relative risks of BCTB were estimated using incidence rate ratios (IRRs) and a Poisson regression analysis.
resultsDuring the study period, 380 of 34,783 cancer patients and 79 of 69,566 control subjects developed BCTB, yielding respective incidence rates of 535 and 37/100,000 person-years, respectively. In all cancer cases, the IRR of BCTB was 14.30, and especially high rates were associated with the following cancers: esophageal cancer (74.72), multiple myeloma (70.76), lung cancer (50.35), pancreatic cancer (46.04), leukemia (40.45), head and neck cancer (24.60), and lymphoma (22.67).
conclusionsThe incidence of active TB was higher in cancer patients than in control subjects. In particular, lung cancer, esophageal cancer, pancreatic cancer, hematologic malignancy and head and neck cancer were identified as high-risk factors for active TB, as indicated by IRRs of 20-75. These findings suggest that patients with high-risk cancers should be targeted for LTBI screening and treatment.
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