Evidence map›Paper›PMID 33144926›Full record

ArticleJournal of extracellular vesicles2020

The future of Extracellular Vesicles as Theranostics - an ISEV meeting report.

Carolina Soekmadji, Bo Li, Yiyao Huang, Haifang Wang, Taixue An, Chunchen Liu, Weilun Pan, Jing Chen, Lesley Cheung, Juan Manuel Falcon-Perez and 16 more

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Carolina SoekmadjiDepartment of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-6920-6627
Bo LiDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-6129-321X
Yiyao HuangDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0003-1749-963X
Haifang WangDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Taixue AnDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Chunchen LiuDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Weilun PanDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jing ChenDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Lesley CheungThe Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.
Juan Manuel Falcon-PerezExosomes Laboratory and Metabolomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.
Yong Song GhoLaboratory of Intercellular Communication, Department of Life Science, POSTECH, South Korea.
Harry B HolthoferMedical Department, University Medical Center Hamburg-Eppendorf, Germany.
Minh T N LeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID https://orcid.org/0000-0002-6077-1566
Antonio MarcillaÀrea De Parasitologia, Departament De Farmàcia I Tecnologia Farmacèutica I Parasitologia, Universitat De València, Burjassot, Valencia, Spain.
Lorraine O'DriscollSchool of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-9860-8262
Faezeh ShekariDepartment of Stem Cells and Developmental BiologyCell Science, Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Tang Long ShenDepartment of Plant Pathology and Microbiology & Center for Biotechnology, National Taiwan University, Taipei, Taiwan.
Ana Claudia TorrecilhasDepartamento De Ciências Farmacêuticas, UNIFESP, Diadema, São Paulo, Brazil.
Xiaomei YanDepartment of Chemical Biology, the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China.ORCID https://orcid.org/0000-0002-7482-6863
Fuquan YangLaboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Hang YinSchool of Pharmaceutical Sciences, Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, China.
Yu XiaoLaboratory of Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0003-1521-9059
Zezhou ZhaoDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-4792-6073
Xue ZouCenter for Public Health Research, Medical School, Nanjing University, Nanjing, China.
Qian WangLaboratory of Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-0299-4462
Lei ZhengDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0003-2576-8780

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on "EVs in Clinical Theranostic". Here, we report the conclusions of roundtable discussions on the current advancement in the analysis technologies and we provide some guidelines to researchers in the field to consider the use of EVs in clinical application. The main challenges and the requirements for EV separation and characterization strategies, quality control and clinical investigation were discussed to promote the application of EVs in future clinical studies.

Indexed as

biomarkerExtracellular vesiclestheranostictherapy

Identifiers

PMID33144926
PMCPMC7580849

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.