ArticleBiochip journal2020
Simultaneous Multiplexed Detection of Protein and Metal Ions by a Colorimetric Microfluidic Paper-based Analytical Device.
Article in Biochip journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Recent Advances in Paper-Based Microfluidic Devices for Heavy Metal Ion Detection: A Review.Micromachines · 2026Review
- Paper-Based Microfluidic Chips for At-Home Point-of-Care Nucleic Acid Testing: Applications and Challenges.Diagnostics (Basel, Switzerland) · 2026Review
- Paper-Based Microfluidic Devices: A Powerful Strategy for Rapid Detection.Micromachines · 2025Review
- Deep eutectic solvent-assisted chemosensing of Fe(iii), V(iii), C(ii), and P(ii) ions using a paper-based micro-array decorated by silver nanoparticles.RSC advances · 2025Article
- Mass Production and Outside Test of Microfluidic Paper Based Analysis Devices for Determining Chromium Ions in Industrial Wastewater.ACS omega · 2025Article
- Intermolecular Structure Conversion-Based G4-TDF Nanostructures Functionalized μPADs for Fluorescent Determination of Potassium Ion in Serum.Biosensors · 2025Article
- Advancements of paper-based microfluidics and organ-on-a-chip models in cosmetics hazards.RSC advances · 2025Review
- Development of a Semiquantitative Barcode Readout Approach for Paper-Based Analytical Devices (PADs) for Enzymatic HAnalytical chemistry · 2025Article
- Real-World Implementation of Particle-Based Microfluidics: On-Spot Test for Iron and Copper Ions in Water.ACS omega · 2025Article
- Distance-based paper microfluidic devices for rapid visual quantification of heavy metals in herbal supplements and cosmetics.RSC advances · 2024Article
- Point-of-Care Devices for Viral Detection: COVID-19 Pandemic and Beyond.Micromachines · 2023Review
- Biomarker Detection in Early Diagnosis of Cancer: Recent Achievements in Point-of-Care Devices Based on Paper Microfluidics.Biosensors · 2023Review
- Simultaneous Cross-type Detection of Water Quality Indexes via a Smartphone-App Integrated Microfluidic Paper-Based Platform.ACS omega · 2022Article
- Recent advances in nephropathy biomarker detections using paper-based analytical devices.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022Review
- Current Advances in Paper-Based Biosensor Technologies for Rapid COVID-19 Diagnosis.Biochip journal · 2022Review
- A simple strategy for signal enhancement in lateral flow assays using superabsorbent polymers.Mikrochimica acta · 2021Article
- Nanomaterial-Integrated Cellulose Platforms for Optical Sensing of Trace Metals and Anionic Species in the Environment.Sensors (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to improve the efficiency of disease diagnosis and environmental monitoring, it is desirable to detect the concentration of proteins and metal ions simultaneously, since the current popular diagnostic platform can only detect proteins or metal ions independently. In this work, we developed a colorimetric microfluidic paper-based analytical device (µPAD) for simultaneous determination of protein (bovine serum albumin, BSA) and metal ions [Fe(III) and Ni(II)]. The µPAD consisted of one central zone, ten reaction zones and ten detection zones in one device, in which reaction solutions were effectively optimized for different types of chromogenic reactions. Fe(III), Ni(II) and BSA can be easily identified by the colored products, and their concentrations are in good accordance with color depth based on the established standard curves. The detection limits are 0.1 mM for Fe(III), 0.5 mM for Ni(II) and 1µM for BSA, respectively. Best of all, we demonstrated the efficiency of the µPAD with accurate detection of Fe(III), Ni (II) and BSA from river water samples within 15 minutes. The µPAD detection is efficient, instrument-free, and easy-to-use, holding great potential for simultaneous detection of cross type analytes in numerous diagnostic fields.
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