Evidence map›Paper›PMID 33144919›Full record

ArticleOncotarget2020

Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer.

Archya Dasgupta, Stephen Brade, Lakshmanan Sannachi, Karina Quiaoit, Kashuf Fatima, Daniel DiCenzo, Laurentius O Osapoetra, Murtuza Saifuddin, Maureen Trudeau, Sonal Gandhi and 7 more

Abstract read
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Archya DasguptaDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Stephen BradeDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Lakshmanan SannachiDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Karina QuiaoitDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Kashuf FatimaDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Daniel DiCenzoDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Laurentius O OsapoetraDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Murtuza SaifuddinDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Maureen TrudeauDepartment of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.
Sonal GandhiDepartment of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.
Andrea EisenDepartment of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.
Frances WrightDepartment of Surgical Oncology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Canada.
Nicole Look-HongDepartment of Surgical Oncology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Canada.
Ali Sadeghi-NainiDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
William T TranDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.
Belinda CurpenDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Canada.
Gregory J CzarnotaDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate quantitative ultrasound (QUS) based higher-order texture derivatives in predicting the response to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC). MATERIALS AND

methods100 Patients with LABC were scanned before starting NAC. Five QUS parametric image-types were generated from radio-frequency data over the tumor volume. From each QUS parametric-image, 4 grey level co-occurrence matrix-based texture images were derived (20 QUS-Tex

resultsA KNN-model provided the best results with sensitivity, specificity, accuracy, and area under curve (AUC) of 87%, 81%, 82%, and 0.86, respectively. The most helpful features in separating the two response groups were QUS-Tex

conclusionsWe report the first study demonstrating QUS texture-derivative methods in predicting NAC responses in LABC, which leads to better results compared to using texture features alone.

Indexed as

breast cancerneoadjuvant chemotherapyquantitative ultrasoundradiomicstexture derivatives

Identifiers

PMID33144919
PMCPMC7584238

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.