Evidence map›Paper›PMID 33144709›Full record

ReviewMolecular psychiatry2021

Diet and depression: exploring the biological mechanisms of action.

Wolfgang Marx, Melissa Lane, Meghan Hockey, Hajara Aslam, Michael Berk, Ken Walder, Alessandra Borsini, Joseph Firth, Carmine M Pariante, Kirsten Berding and 16 more

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 331 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
331citing papers in PubMed, 13 pooled it
33.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

331 citing papers in PubMed, 13 syntheses or guidelines pooled it, 605 citations in OpenAlex.

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271 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 11 institutions in 9 countries.

Wolfgang MarxDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Geelong, VIC, Australia. wolf.marx@deakin.edu.au.ORCID http://orcid.org/0000-0002-8556-8230
Melissa LaneDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Geelong, VIC, Australia.
Meghan HockeyDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Geelong, VIC, Australia.
Hajara AslamDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Geelong, VIC, Australia.
Michael BerkDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Geelong, VIC, Australia.
Ken WalderDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Metabolic Research Unit, Geelong, VIC, Australia.
Alessandra BorsiniDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4410-7865
Joseph FirthDivision of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Carmine M ParianteDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9132-5091
Kirsten BerdingAPC Microbiome Ireland, University College Cork, Cork, Ireland.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0001-5887-2723
Gerard ClarkeAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0001-9771-3979
Jeffrey M CraigDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, Australia.
Kuan-Pin SuDepartments of Psychiatry and Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.ORCID http://orcid.org/0000-0002-4501-2502
David MischoulonDepartment of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Fernando Gomez-PinillaDepartments of Neurosurgery and Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Jane A FosterDepartment of Psychiatry & Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-8579-4705
Patrice D CaniUCLouvain, Université catholique de Louvain, WELBIO-Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium.
Sandrine ThuretBasic and Clinical Neuroscience Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1260-8083
Heidi M StaudacherDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Geelong, VIC, Australia.
Almudena Sánchez-VillegasNutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Gran Canaria, Spain.
Husnain ArshadUniversité Paris-Saclay, UVSQ, Inserm, CESP, "DevPsy", 94807, Villejuif, France.
Tasnime AkbaralyUniversité Paris-Saclay, UVSQ, Inserm, CESP, "DevPsy", 94807, Villejuif, France.ORCID http://orcid.org/0000-0002-2150-4190
Adrienne O'NeilDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Geelong, VIC, Australia.
Toby SegasbyBasic and Clinical Neuroscience Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.
Felice N JackaDeakin University, IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0002-9825-0328
Deakin University · AUKing's College London · GBUniversity College Cork · IEInserm · FRChina Medical University · TWHarvard University · USMcMaster University · CAUniversidad de Las Palmas de Gran Canaria · ESUniversity of California, Los Angeles · USUniversity of Manchester · GBWalloon Excellence in Lifesciences and Biotechnology · BE

Funding

Medical Research Council G108/603Medical Research Council MR/J002739/1Medical Research Council MR/L014815/1Medical Research Council MR/N029488/1Medical Research Council MR/N030087/1Medical Research Council MR/S00484X/1
6 · The paper itself

Abstract

The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted dietary therapies, this review provides an overview of what is currently known regarding underlying mechanisms of action by which diet may influence mental and brain health. The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway. Numerous pathways were identified through which diet could plausibly affect mental health. These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity. However, the nascent nature of the nutritional psychiatry field to date means that the existing literature identified in this review is largely comprised of preclinical animal studies. To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed.

Indexed as

AnimalsDepressionDietEpigenesis, GeneticGastrointestinal MicrobiomeHumansInflammationOxidative Stress

Identifiers

PMID33144709
OpenAlexW3092306005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.