Evidence map›Paper›PMID 33144694›Full record

ArticleBritish journal of cancer2021

Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion.

Alvin Kunyao Guo, Yoko Itahana, Veerabrahma Pratap Seshachalam, Hui Ying Chow, Sujoy Ghosh, Koji Itahana

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Mutant p53Molecular oncology · 2026
    Article
  2. Article
  3. Article
  4. Exploring the Therapeutic Potential ofInternational journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Multi-Omics Analysis of the Effects of Smoking on Human Tumors.Frontiers in molecular biosciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alvin Kunyao GuoCancer and Stem Cell Biology Programme, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.ORCID http://orcid.org/0000-0003-0772-1030
Yoko ItahanaCancer and Stem Cell Biology Programme, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.ORCID http://orcid.org/0000-0003-3560-4560
Veerabrahma Pratap SeshachalamCentre for Computational Biology, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
Hui Ying ChowSchool of Applied Science, Temasek Polytechnic, 21 Tampines Avenue 1, Singapore, 529757, Singapore.
Sujoy GhoshCentre for Computational Biology, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
Koji ItahanaCancer and Stem Cell Biology Programme, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore. koji.itahana@duke-nus.edu.sg.ORCID http://orcid.org/0000-0002-7241-2894
Duke-NUS Medical School · SGTemasek Polytechnic · SG

Funding

Ministry of Education - Singapore (MOE) MOE 2017-T2-1-081MOH | National Medical Research Council (NMRC) NMRC/OFIRG/0006/2016
6 · The paper itself

Abstract

backgroundMutant TP53 interacts with other proteins to produce gain-of-function properties that contribute to cancer metastasis. However, the underlying mechanisms are still not fully understood.

methodsUsing immunoprecipitation and proximity ligation assays, we evaluated breast cancer anti-estrogen resistance 1 (BCAR1) as a novel binding partner of TP53

resultsWe discovered a novel interaction between TP53

conclusionsThe interaction between TP53

Indexed as

Cell Line, TumorCrk-Associated Substrate ProteinHumansMutationNeoplasm InvasivenessTumor Suppressor Protein p53BCAR1 protein, humanCrk-Associated Substrate ProteinTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID33144694
PMCPMC7782524
OpenAlexW3097405930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.