Evidence map›Paper›PMID 33144672›Full record

ArticleScientific reports2020

Effect of the similarity of gut microbiota composition between donor and recipient on graft function after living donor kidney transplantation.

Ji Eun Kim, Hyo-Eun Kim, Hyunjeong Cho, Ji In Park, Min-Jung Kwak, Byung-Yong Kim, Seung Hee Yang, Jung Pyo Lee, Dong Ki Kim, Kwon Wook Joo and 3 more

Abstract readComparative Study
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Kidney transplantation and gut microbiota.Clinical kidney journal · 2024
    Review
  10. Review
  11. The Effect of the Gut Microbiota on Transplanted Kidney Function.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Gut Dysbiosis and Kidney Diseases.Frontiers in medicine · 2022
    Review
  14. Intestinal microbiota and kidney diseases.Kidney research and clinical practice · 2021
    Article
  15. Influence of the microbiome on solid organ transplant survival.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ji Eun KimDepartment of Internal Medicine, Seoul National University Hospital, 103 Daehakro, Jongno-gu, Seoul, 03080, Republic of Korea.
Hyo-Eun KimBiomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Hyunjeong ChoDepartment of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Ji In ParkDepartment of Internal Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea.
Min-Jung KwakChunLab, Inc, Seoul, Republic of Korea.
Byung-Yong KimChunLab, Inc, Seoul, Republic of Korea.
Seung Hee YangKidney Research Institute, Seoul National University, Seoul, Republic of Korea.
Jung Pyo LeeDepartment of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea.
Dong Ki KimDepartment of Internal Medicine, Seoul National University Hospital, 103 Daehakro, Jongno-gu, Seoul, 03080, Republic of Korea.
Kwon Wook JooDepartment of Internal Medicine, Seoul National University Hospital, 103 Daehakro, Jongno-gu, Seoul, 03080, Republic of Korea.
Yon Su KimDepartment of Internal Medicine, Seoul National University Hospital, 103 Daehakro, Jongno-gu, Seoul, 03080, Republic of Korea.
Bong-Soo KimDepartment of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of Korea.
Hajeong LeeDepartment of Internal Medicine, Seoul National University Hospital, 103 Daehakro, Jongno-gu, Seoul, 03080, Republic of Korea. mdhjlee@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graft outcomes of unrelated donor kidney transplant are comparable with those of related donor kidney transplant despite their genetic distance. This study aimed to identify whether the similarity of donor-recipient gut microbiota composition affects early transplant outcomes. Stool samples from 67 pairs of kidney transplant recipients and donors were collected. Gut microbiota differences between donors and recipients were determined using weighted UniFrac distance. Among the donor-recipient pairs, 30 (44.8%) pairs were related, while 37 (55.2%) were unrelated. The unrelated pairs, especially spousal pairs, had similar microbial composition, and they more frequently shared their meals than related pairs did. The weighted UniFrac distance showed an inverse correlation with the 6-month allograft function (p = 0.034); the correlation was significant in the unrelated pairs (p = 0.003). In the unrelated pairs, the microbial distance showed an excellent accuracy in predicting the estimated glomerular filtration rate of < 60 mL/min/1.73 m

Indexed as

Living DonorsAdultBacteriaCommunicable DiseasesFemaleGastrointestinal MicrobiomeGlomerular Filtration RateHumansIncidenceKidneyKidney TransplantationMaleMiddle AgedPhylogenySequence Analysis, DNATransplant Recipients

Identifiers

PMID33144672
PMCPMC7641223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.